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Shared name	type	polarity	annotation
4EBP1#pro ⇨ 4EBP1\|active#pro	STATE_TRANSITION	0	12172553
4EBP1\|active#pro ⇨ 4EBP1\|_pho#pro	STATE_TRANSITION	0	24240150,10567225,15094766
4EBP1\|active+eIF4E#com ⇨ 4EBP1\|_pho#pro	DISSOCIATION	0	24240150
4EBP1\|active+eIF4E#com ⇨ eIF4E\|_pho\|active#pro	DISSOCIATION	0	24240150
5-lipoxygenase#pro ⇨ 5-lipoxygenase\|active#pro	STATE_TRANSITION	0	2545780,19075240
5-lipoxygenase\|active#pro ⇨ LTA_4#sim	CATALYSIS	1	6311078
A20#pro ⇨ IKK _gamma_#pro	CATALYSIS	1	22099304
AKT#pro ⇨ AKT\|_pho\|active#pro	STATE_TRANSITION	0	9094314
AKT\|_pho\|active#pro ⇨ AKT#pro	STATE_TRANSITION	0	11598301
AKT\|_pho\|active#pro ⇨ BAD\|_pho#pro	CATALYSIS	1	9381178,9346240,14678993
AKT\|_pho\|active#pro ⇨ Caspase-9\|_pho#pro	CATALYSIS	1	10529400,12792650
AKT\|_pho\|active#pro ⇨ FKHRL1\|_pho#pro	CATALYSIS	1	10102273
AKT\|_pho\|active#pro ⇨ GSK3\|Ser_pho#pro	CATALYSIS	1	8524413
AKT\|_pho\|active#pro ⇨ HIF-1_alpha_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	12213597
AKT\|_pho\|active#pro ⇨ Rac+Rap1a+gp91_phox+p22_phox+p40_phox+p47_phox+p67_phox#com	CATALYSIS	1	22544939,18094534,17277894
AKT\|_pho\|active#pro ⇨ TSC1/2\|_pho#pro	CATALYSIS	1	15094766,12172553,15851026
AKT\|_pho\|active#pro ⇨ eNOS\|_pho\|active#pro	CATALYSIS	1	10376602,10376603
AKT\|_pho\|active#pro ⇨ mTOR\|_pho\|active#pro	CATALYSIS	1	10910062,24121838,15094766
AKT\|_pho\|active#pro ⇨ p27 KIP1\|_pho#pro	CATALYSIS	1	12146978
AKT\|_pho\|active#pro ⇨ p27 KIP1\|active#pro	BRIDGED:INHIBITION+TRANSLATION	-1	10827191,11094066
AMPK#pro ⇨ TSC1/2\|_pho\|active#pro	CATALYSIS	1	14651849
AP1#pro ⇨ AP1\|_pho\|active#pro	STATE_TRANSITION	0	8137421,8912180
AP1\|_pho\|active#pro ⇨ AP1\|_pho+PPAR_gamma_#com	HETERODIMER_ASSOCIATION	0	17277894
AP1\|_pho\|active#pro ⇨ CXCL1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	20671197,18250465
AP1\|_pho\|active#pro ⇨ CXCL2#pro	BRIDGED:CATALYSIS+TRANSLATION	1	24280128,23024284,20671197
AP1\|_pho\|active#pro ⇨ FasL CD178#pro	BRIDGED:CATALYSIS+TRANSLATION	1	12655294
AP1\|_pho\|active#pro ⇨ _beta_-defensin#pro	BRIDGED:CATALYSIS+TRANSLATION	1	20615218
AP1\|_pho\|active#pro ⇨ miR-155#ant	CATALYSIS	1	18515182,17242365
ASK1#pro ⇨ ASK1\|active#pro	STATE_TRANSITION	0	9774977
ASK1\|active#pro ⇨ MKK3\|_pho\|active#pro	CATALYSIS	1	8974401
ASK1\|active#pro ⇨ MKK4\|_pho\|active#pro	CATALYSIS	1	9639556,8974401
ATF-1#pro ⇨ ATF-1\|_pho\|active#pro	STATE_TRANSITION	0	8887554
ATF-1\|_pho\|active#pro ⇨ IL-10#pro	BRIDGED:CATALYSIS+TRANSLATION	1	10903771,20154735,16713974,23814099,24835395
ATF-2#pro ⇨ ATF-2\|_pho\|active#pro	STATE_TRANSITION	0	7824938,7535770,7824938
ATF-2\|_pho\|active#pro ⇨ IFN-_gamma_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8700208,9834094,1602132,23630228
ATF-2\|_pho\|active#pro ⇨ SOCS3#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22973511,23219158,15032587,10433356,19422799,18291670,24607843
ATF-2\|_pho\|active#pro ⇨ c-jun#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7709430,8912180
ATP#sim ⇨ ATP+P2X_7#com	HETERODIMER_ASSOCIATION	0	25295542
ATP+P2X_7#com ⇨ Nalp3\|active#pro	CATALYSIS	1	25295542
BAD\|active#pro ⇨ BAD\|_pho#pro	STATE_TRANSITION	0	9381178,9346240,14678993
Bcl10#pro ⇨ Bcl10+CARD9\|_pho+MALT#com	HETERODIMER_ASSOCIATION	0	23523010,16862125
Bcl10+CARD9\|_pho+MALT#com ⇨ TAK1\|_pho\|active#pro	CATALYSIS	1	23523010
Btk#pro ⇨ Btk\|active#pro	STATE_TRANSITION	0	22101734
Btk\|active#pro ⇨ PI3K\|active#pro	CATALYSIS	1	12958648,2399454,7713890,17016431,15313431,18411281,22101734
Btk\|active#pro ⇨ PLC_gamma_\|active#pro	CATALYSIS	1	22101734
Btk\|active#pro ⇨ _alpha_4+_beta_1#com	BRIDGED:PHYSICAL_STIMULATION+KNOWN_TRANSITION_OMITTED	1	22101734,22101734
Btk\|active#pro ⇨ _alpha_M+_beta_2#com	BRIDGED:PHYSICAL_STIMULATION+KNOWN_TRANSITION_OMITTED	1	22101734,22101734
C/EBP_alpha_#pro ⇨ C/EBP_alpha_\|S21_pho#pro	STATE_TRANSITION	0	19587381
C/EBP_alpha_#pro ⇨ IL-10#pro	BRIDGED:INHIBITION+TRANSLATION	-1	10903771,20154735,16713974,23814099,24835395
C/EBP_alpha_#pro ⇨ TNFR#pro	BRIDGED:CATALYSIS+TRANSLATION	1	19523687
C/EBP_beta_\|active#pro ⇨ CCL3#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22147692,22732594
C/EBP_beta_\|active#pro ⇨ IL-10#pro	BRIDGED:CATALYSIS+TRANSLATION	1	10903771,20154735,16713974,23814099,24835395
C/EBP_beta_\|active#pro ⇨ TNF#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22312110,2181276,22147692,23177475,15811878,23630228,18515182,18291670
C/EBP_beta_\|active#pro ⇨ TNFR#pro	BRIDGED:CATALYSIS+TRANSLATION	1	19523687
C/EBP_delta_\|active#pro ⇨ IL-6#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22312110,2405250,2786029,15811878,23177475,18515182
C/EBP_delta_\|active#pro ⇨ TNF#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22312110,2181276,22147692,23177475,15811878,23630228,18515182,18291670
C/EBP_epsilon_#pro ⇨ CAP-18 LL-37#pro	BRIDGED:CATALYSIS+TRANSLATION	1	24246949
C5a anaphylatoxin+C5aRI (CD88)+C5aRII (C5l2)#com ⇨ PI3K\|active#pro	CATALYSIS	1	12958648,2399454,7713890,17016431,15313431,18411281,22101734
C5a anaphylatoxin+C5aRI (CD88)+C5aRII (C5l2)#com ⇨ PLC_beta_\|active#pro	CATALYSIS	1	8316840,12958648,23994549,15313431,18411281
C5a anaphylatoxin+C5aRI (CD88)+C5aRII (C5l2)#com ⇨ adenylate cyclase\|active#pro	CATALYSIS	1	12958648,23994549
C5a anaphylatoxin+C5aRI (CD88)+C5aRII (C5l2)#com ⇨ p38\|_pho\|active#pro	UNKNOWN_CATALYSIS	1	15313431
CARD9#pro ⇨ CARD9\|_pho#pro	STATE_TRANSITION	0	23523010,16862125
CARD9#pro ⇨ CARD9\|active#pro	STATE_TRANSITION	0	17187069
CARD9\|_pho#pro ⇨ Bcl10+CARD9\|_pho+MALT#com	HETERODIMER_ASSOCIATION	0	23523010,16862125
CARD9\|active#pro ⇨ JNK\|_pho\|active#pro	CATALYSIS	1	7839144,8621675,19043549,17187069,17348859,15032587
CARD9\|active#pro ⇨ p38\|_pho\|active#pro	CATALYSIS	1	7839144,8621675,19043549,17187069,17348859,15032587,11585703
CBP+PPAR_gamma_#com ⇨ iNOS#pro	BRIDGED:INHIBITION+TRANSLATION	-1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
CBP\|active#pro ⇨ CBP+PPAR_gamma_#com	HETERODIMER_ASSOCIATION	0	17277894,10075656
CCL2+CCR2+G protein _alpha__beta__gamma_+GTP#com ⇨ PLC_beta_\|active#pro	CATALYSIS	1	8316840,12958648,23994549,15313431,18411281
CCL2+CCR2+G protein _alpha__beta__gamma_+GTP#com ⇨ adenylate cyclase\|active#pro	CATALYSIS	1	12958648,23994549
CCL3+CCR1+G protein _alpha__beta__gamma_+GTP#com ⇨ PI3K\|active#pro	CATALYSIS	1	12958648,2399454,7713890,17016431,15313431,18411281,22101734
CCL3+CCR1+G protein _alpha__beta__gamma_+GTP#com ⇨ PLC_beta_\|active#pro	CATALYSIS	1	8316840,12958648,23994549,15313431,18411281
CCL3+CCR1+G protein _alpha__beta__gamma_+GTP#com ⇨ adenylate cyclase\|active#pro	CATALYSIS	1	12958648,23994549
CCL5+CCR3#com ⇨ PI3K\|active#pro	CATALYSIS	1	12958648,2399454,7713890,17016431,15313431,18411281,22101734
CCL5+CCR3#com ⇨ Rac\|active#pro	CATALYSIS	1	15292195
CD14+LPS+MD-2+TLR4#com ⇨ HO-1\|active#pro	KNOWN_TRANSITION_OMITTED	0	25295542
CD14+LPS+MD-2+TLR4#com ⇨ IRAK1\|_pho\|active+IRAK4\|_pho\|active+MyD88\|hm2+TRAF6\|K63_ubi\|_pho#com	KNOWN_TRANSITION_OMITTED	0	10075645
CD14+LPS+MD-2+TLR4#com ⇨ MyD88\|hm2+TIRAP#com	CATALYSIS	1	15229469
CD14+LPS+MD-2+TLR4#com ⇨ TRIF\|hm2\|active#pro	CATALYSIS	1	15229469,12855817
CD4+IL-16#com ⇨ JNK\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	9637499,10857846
CD4+IL-16#com ⇨ p38\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	9637499,10857846
CIS#pro ⇨ STAT5\|hm2\|Y_pho\|active#pro	INHIBITION	-1	12563297,23219158
CREB#pro ⇨ CREB\|_pho\|active#pro	STATE_TRANSITION	0	9687510,9242925
CREB\|_pho\|active#pro ⇨ IL-10#pro	BRIDGED:CATALYSIS+TRANSLATION	1	10903771,20154735,16713974,23814099,24835395
CREB\|_pho\|active#pro ⇨ MIF#pro	BRIDGED:CATALYSIS+TRANSLATION	1	18034423
CTMP#pro ⇨ AKT#pro	CATALYSIS	1	11598301
CXCL10+CXCR3#com ⇨ PLC_beta_\|active#pro	CATALYSIS	1	8316840,12958648,23994549,15313431,18411281
CXCL10+CXCR3#com ⇨ adenylate cyclase\|active#pro	INHIBITION	-1	12958648,23994549
CXCL10+CXCR3#com ⇨ c-Src\|_pho\|active#pro	CATALYSIS	1	23994549,6283105
CXCL8+CXCR1+CXCR2+G protein _alpha__beta__gamma_+GTP#com ⇨ PLC_beta_\|active#pro	CATALYSIS	1	8316840,12958648,23994549,15313431,18411281
CXCL8+CXCR1+CXCR2+G protein _alpha__beta__gamma_+GTP#com ⇨ adenylate cyclase\|active#pro	CATALYSIS	1	12958648,23994549
CXCL8+CXCR1+CXCR2+G protein _alpha__beta__gamma_+GTP#com ⇨ c-Src\|_pho\|active#pro	CATALYSIS	1	23994549,6283105
CXCL9+CXCR3+G protein _alpha__beta__gamma_+GTP#com ⇨ PLC_beta_\|active#pro	CATALYSIS	1	8316840,12958648,23994549,15313431,18411281
CXCL9+CXCR3+G protein _alpha__beta__gamma_+GTP#com ⇨ adenylate cyclase\|active#pro	CATALYSIS	1	12958648,23994549
CXCL9+CXCR3+G protein _alpha__beta__gamma_+GTP#com ⇨ c-Src\|_pho\|active#pro	CATALYSIS	1	23994549,6283105
CaM+iNOS#com ⇨ L-citrulline#sim	CATALYSIS	1	1696255
CaM+iNOS#com ⇨ NADP_+#sim	CATALYSIS	1	1696255
CaM+iNOS#com ⇨ NO#ion	CATALYSIS	1	1696255
Ca_2+#ion ⇨ PLD\|active#pro	CATALYSIS	1	7510960,17631865,18569866
Caspase-11#pro ⇨ Caspase-11\|active#pro	STATE_TRANSITION	0	23307811
Caspase-11\|active#pro ⇨ Caspase-1\|active#pro	CATALYSIS	1	11390368,19915568,23307811,22753929
Caspase-1\|active#pro ⇨ Caspase-7#pro	CATALYSIS	1	19343209
Caspase-1\|active#pro ⇨ IL-18#pro	CATALYSIS	1	24115947
Caspase-1\|active#pro ⇨ IL-1_beta_#pro	CATALYSIS	1	1574116
Caspase-9\|active#pro ⇨ Caspase-9\|_pho#pro	STATE_TRANSITION	0	10529400,12792650
CpG / DNA+TLR9#com ⇨ MyD88\|hm2\|active#pro	CATALYSIS	1	15229469
DAG#sim ⇨ PKC\|active#pro	CATALYSIS	1	3321305
DAP12#pro ⇨ DAP12\|Y_pho#pro	STATE_TRANSITION	0	22101734,17086186
DAP12\|Y_pho#pro ⇨ Syk\|Tyr519_pho\|Tyr518_pho\|active#pro	CATALYSIS	1	22101734,17086186,17110948
DUSP1#pro ⇨ p38#pro	CATALYSIS	1	16380512
ECSIT#pro ⇨ ECSIT+MEKK1\|active+TAB1+TAB2\|_pho+TAK1\|_pho\|active+TRAF6\|K63_ubi\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	12242293,10465784
ECSIT+MEKK1\|active+TAB1+TAB2\|_pho+TAK1\|_pho\|active+TRAF6\|K63_ubi\|_pho\|active#com ⇨ IKK _alpha_\|_pho\|active#pro	CATALYSIS	1	11460167
ECSIT+MEKK1\|active+TAB1+TAB2\|_pho+TAK1\|_pho\|active+TRAF6\|K63_ubi\|_pho\|active#com ⇨ IKK _beta_\|_pho\|active#pro	CATALYSIS	1	11460167,16125763
ECSIT+MEKK1\|active+TAB1+TAB2\|_pho+TAK1\|_pho\|active+TRAF6\|K63_ubi\|_pho\|active#com ⇨ MKK4\|_pho\|active#pro	CATALYSIS	1	9079627
ECSIT+MEKK1\|active+TAB1+TAB2\|_pho+TAK1\|_pho\|active+TRAF6\|K63_ubi\|_pho\|active#com ⇨ NIK\|active#pro	CATALYSIS	1	10094049
EGF+EGFR#com ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,9096689,2198577,6610834,7534287
EGF+EGFR#com ⇨ PI3K\|active#pro	CATALYSIS	1	1380456,10805725,23219158,22544939,15292195,11289110,11585703,1370584
EGF+EGFR#com ⇨ PLC_gamma_\|active#pro	CATALYSIS	1	1501243
ELK#pro ⇨ ELK\|_pho\|active#pro	STATE_TRANSITION	0	8846788,8978682
ELK\|_pho\|active#pro ⇨ c-fos#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7709430,8912180,2452846,21385848
EP+G protein _alpha__beta__gamma_+GTP+PGE_2#com ⇨ PI3K\|active#pro	CATALYSIS	1	22012553
EP+G protein _alpha__beta__gamma_+GTP+PGE_2#com ⇨ PLC_beta_\|active#pro	CATALYSIS	1	22012553,14617636
EP+G protein _alpha__beta__gamma_+GTP+PGE_2#com ⇨ adenylate cyclase\|active#pro	CATALYSIS	1	22012553,14617636
EP+G protein _alpha__beta__gamma_+GTP+PGE_2#com ⇨ adenylate cyclase\|active#pro_1	INHIBITION	-1	22012553
ERK#pro ⇨ ERK\|_pho\|active#pro	STATE_TRANSITION	0	10530871
ERK\|_pho\|active#pro ⇨ C/EBP_alpha_\|S21_pho#pro	CATALYSIS	1	19587381
ERK\|_pho\|active#pro ⇨ Caspase-9\|_pho#pro	CATALYSIS	1	10529400,12792650
ERK\|_pho\|active#pro ⇨ ELK\|_pho\|active#pro	CATALYSIS	1	7889942
ERK\|_pho\|active#pro ⇨ Ets\|_pho\|active#pro	CATALYSIS	1	8108135
ERK\|_pho\|active#pro ⇨ HIF-1_alpha_\|_pho+HIF-1_beta_#com	CATALYSIS	1	10551817,11585703,12213597
ERK\|_pho\|active#pro ⇨ MAPKAPK2\|_pho\|active#pro	CATALYSIS	1	8666821
ERK\|_pho\|active#pro ⇨ MNK 1/2\|_pho\|active#pro	CATALYSIS	1	9155017
ERK\|_pho\|active#pro ⇨ MSK 1/2\|_pho\|active#pro	CATALYSIS	1	9687510
ERK\|_pho\|active#pro ⇨ Mdm2+p53\|_pho#com	CATALYSIS	1	7890669,7510706,9607138
ERK\|_pho\|active#pro ⇨ STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro	CATALYSIS	1	8557638,15266021,7543024
ERK\|_pho\|active#pro ⇨ STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro	CATALYSIS	1	9343414,7543024
ERK\|_pho\|active#pro ⇨ Smad6/7 (I-Smads)#pro	BRIDGED:CATALYSIS+TRANSLATION	1	9759503,10652273,9335507
ERK\|_pho\|active#pro ⇨ TSC1/2\|_pho#pro	CATALYSIS	1	15094766,12172553,15851026
ERK\|_pho\|active#pro ⇨ c-Myc#pro	BRIDGED:CATALYSIS+TRANSLATION	1	9464539
ERK\|_pho\|active#pro ⇨ c-Myc\|_pho\|active#pro	CATALYSIS	1	11018017
ERK\|_pho\|active#pro ⇨ c-fos\|_pho+c-jun\|_pho#com	CATALYSIS	1	8170999,8912180
ERK\|_pho\|active#pro ⇨ p90RSK\|_pho\|active#pro	CATALYSIS	1	2842685
Ets#pro ⇨ Ets\|_pho\|active#pro	STATE_TRANSITION	0	8108135
Ets\|_pho\|active#pro ⇨ FasL CD178#pro	BRIDGED:CATALYSIS+TRANSLATION	1	12655294
FADD+Fas CD95+FasL CD178+procaspase-8#com ⇨ Caspase-8\|hm2\|active#pro	CATALYSIS	1	15491504,9880531,15317488
FGF+FGFR#com ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,9096689,2198577,6610834,7534287
FKHRL1\|active#pro ⇨ FKHRL1\|_pho#pro	STATE_TRANSITION	0	10102273
FKHRL1\|active#pro ⇨ FasL CD178#pro	BRIDGED:CATALYSIS+TRANSLATION	1	12655294
FKHRL1\|active#pro ⇨ p27 KIP1\|active#pro	BRIDGED:CATALYSIS+TRANSLATION	1	10827191,11094066
FLAP#pro ⇨ 5-lipoxygenase\|active#pro	CATALYSIS	1	2545780,19075240
F_c_gamma_R+opsonized bacteria#com ⇨ PKC_delta_\|_pho\|active#pro	CATALYSIS	1	22544939
F_c_gamma_RI (CD64)\|_pho+IgG#com ⇨ Syk\|Tyr519_pho\|Tyr518_pho\|active#pro	CATALYSIS	1	8226994
F_c_gamma_RII (CD32)\|_pho+IgG#com ⇨ SHP1\|active#pro	CATALYSIS	1	9743328
F_c_gamma_RII (CD32)\|_pho+IgG#com ⇨ Syk\|Tyr519_pho\|Tyr518_pho\|active#pro	CATALYSIS	1	8226994
FcR _gamma_#pro ⇨ FcR _gamma_\|Y_pho#pro	STATE_TRANSITION	0	22101734,17086186
FcR _gamma_#pro ⇨ Syk\|Tyr519_pho\|Tyr518_pho\|active#pro	CATALYSIS	1	21677049,23523010,16862125
FcR _gamma_\|Y_pho#pro ⇨ Syk\|Tyr519_pho\|Tyr518_pho\|active#pro	CATALYSIS	1	22101734,17086186,17110948
Fgr\|active#pro ⇨ DAP12\|Y_pho#pro	CATALYSIS	1	22101734,17086186
Fgr\|active#pro ⇨ FcR _gamma_\|Y_pho#pro	CATALYSIS	1	22101734,17086186
Flagellin+Naip5 Birc1e#com ⇨ Caspase-1\|active#pro	CATALYSIS	1	11390368,19915568,23307811,22753929
Flagellin+Naip5 Birc1e#com ⇨ IRF-1\|active+IRF-8\|active#com	UNKNOWN_CATALYSIS	1	19720760
Flagellin+Nlrc4 Ipaf#com ⇨ Caspase-1\|active#pro	CATALYSIS	1	11390368,19915568,23307811,22753929
Flagellin+Nlrc4 Ipaf#com ⇨ IRF-1\|active+IRF-8\|active#com	UNKNOWN_CATALYSIS	1	19720760
Flagellin+TLR5#com ⇨ MyD88\|hm2\|active#pro	CATALYSIS	1	15229469
Fyn#pro ⇨ Fyn\|active#pro	STATE_TRANSITION	0	21321534
Fyn\|active#pro ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,7508932,7513165,22685316
Fyn\|active#pro ⇨ PI3K\|active#pro	CATALYSIS	1	10805725,10473597,15646653
GM-CSF+GM-CSFR_alpha_\|_pho+GM-CSFR_beta_\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active#com ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,7508932,7513165,22685316
GM-CSF+GM-CSFR_alpha_\|_pho+GM-CSFR_beta_\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active#com ⇨ PI3K\|active#pro	CATALYSIS	1	10805725,10473597,15646653
GM-CSF+GM-CSFR_alpha_\|_pho+GM-CSFR_beta_\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active#com ⇨ SHP2\|active#pro	CATALYSIS	1	7522233,19587381
GM-CSF+GM-CSFR_alpha_\|_pho+GM-CSFR_beta_\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active#com ⇨ STAT1\|Y701_pho\|active#pro	CATALYSIS	1	8378775,8631962
GM-CSF+GM-CSFR_alpha_\|_pho+GM-CSFR_beta_\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active#com ⇨ STAT3\|Y705_pho\|active#pro	CATALYSIS	1	8631962,19587381,22685316
GM-CSF+GM-CSFR_alpha_\|_pho+GM-CSFR_beta_\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active#com ⇨ STAT5\|Y_pho\|active#pro	CATALYSIS	1	7720707,22685316
GSK3\|active#pro ⇨ GSK3\|Ser_pho#pro	STATE_TRANSITION	0	8307153
GSK3\|active#pro ⇨ HIF-1_alpha_\|Ser_pho#pro	CATALYSIS	1	20889502,17325032
Grb2#pro ⇨ Grb2\|active+SOS\|active+Shc\|active#com	HETERODIMER_ASSOCIATION	0	8479536,7508932,7513165,22685316
Grb2\|active+SOS\|active+Shc\|active#com ⇨ p21Ras\|active#pro	CATALYSIS	1	7786285,8607978,8479530,8599089
HIF-1_alpha_#pro ⇨ HIF-1_alpha_+HIF-1_beta_#com	HETERODIMER_ASSOCIATION	0	8900415
HIF-1_alpha_#pro ⇨ HIF-1_alpha_+SUMO#com	HETERODIMER_ASSOCIATION	0	17981124
HIF-1_alpha_#pro ⇨ HIF-1_alpha_\|Pro_hyd#pro	STATE_TRANSITION	0	11504942
HIF-1_alpha_#pro ⇨ HIF-1_alpha_\|Ser_pho#pro	STATE_TRANSITION	0	20889502,17325032
HIF-1_alpha_#pro ⇨ HIF-1_alpha_\|_ace#pro	STATE_TRANSITION	0	12464182
HIF-1_alpha_+HIF-1_beta_#com ⇨ HIF-1_alpha_\|_pho+HIF-1_beta_#com	STATE_TRANSITION	0	10551817,11585703,12213597
HIF-1_alpha_+SUMO#com ⇨ HIF-1_alpha_#pro	DISSOCIATION	0	17981124
HIF-1_alpha_+SUMO#com ⇨ SUMO#pro	DISSOCIATION	0	17981124
HIF-1_alpha_\|Pro_hyd#pro ⇨ HIF-1_alpha_\|Pro_hyd+VHL#com	HETERODIMER_ASSOCIATION	0	10878807,11504942
HIF-1_alpha_\|Pro_hyd+VHL#com ⇨ HIF-1_alpha_\|Pro_hyd\|Lys_ubi+VHL#com	STATE_TRANSITION	0	10878807,11504942
HIF-1_alpha_\|_pho+HIF-1_beta_#com ⇨ HO-1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	9038135
HIF-1_alpha_\|_pho+HIF-1_beta_#com ⇨ iNOS#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
HIF-1_beta_#pro ⇨ HIF-1_alpha_+HIF-1_beta_#com	HETERODIMER_ASSOCIATION	0	8900415
HIF-PHD#pro ⇨ HIF-PHD\|active#pro	STATE_TRANSITION	0	21199675
HIF-PHD\|active#pro ⇨ HIF-1_alpha_\|Pro_hyd#pro	CATALYSIS	1	11504942
Hck\|active#pro ⇨ DAP12\|Y_pho#pro	CATALYSIS	1	22101734,17086186
IFN-_alpha_+IFN-_beta_+IFNAR1+IFNAR2#com ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+Tyk2\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	11070173
IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+Tyk2\|_pho\|active#com ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+STAT1\|hm2\|Y701_pho\|active+STAT2\|Y689_pho\|active+Tyk2\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	7504785,7579387
IFN-_gamma_#pro ⇨ IFN-_gamma_+IFNGR1+IFNGR2#com	HETERODIMER_ASSOCIATION	0	8349687
IFN-_gamma_+IFNGR1\|_pho+IFNGR2\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active#com ⇨ Fyn\|active#pro	CATALYSIS	1	21321534
IFN-_gamma_+IFNGR1\|_pho+IFNGR2\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active#com ⇨ IFN-_gamma_+IFNGR1\|_pho+IFNGR2\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+STAT1\|hm2\|Y701_pho\|active#com	HETERODIMER_ASSOCIATION	0	8197455
IFN-_gamma_+IFNGR1\|_pho+IFNGR2\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+STAT1\|hm2\|Y701_pho\|active#com ⇨ IFN-_gamma_+IFNGR1\|_pho+IFNGR2\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active#com	DISSOCIATION	0	1281555
IFN-_gamma_+IFNGR1\|_pho+IFNGR2\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+STAT1\|hm2\|Y701_pho\|active#com ⇨ STAT1\|Y701_pho\|active#pro	DISSOCIATION	0	1281555
IFNGR1#pro ⇨ IFN-_gamma_+IFNGR1+IFNGR2#com	HETERODIMER_ASSOCIATION	0	8349687
IFNGR2#pro ⇨ IFN-_gamma_+IFNGR1+IFNGR2#com	HETERODIMER_ASSOCIATION	0	8349687
IKK _alpha_#pro ⇨ IKK _alpha_\|_pho\|active#pro	STATE_TRANSITION	0	9008162,22289858,9346485,24115947
IKK _alpha_#pro ⇨ IKK _beta_#pro	HETERODIMER_ASSOCIATION	0	10880512,11087742
IKK _alpha_\|_pho\|active#pro ⇨ IRF-5\|K63_ubi\|active#pro	INHIBITION	-1	18824541,19786094
IKK _alpha_\|_pho\|active#pro ⇨ IRF-5\|_pho#pro	CATALYSIS	1	19786094
IKK _alpha_\|_pho\|active#pro ⇨ IRF-7\|_pho\|active#pro	CATALYSIS	1	16612387
IKK _alpha_\|_pho\|active#pro ⇨ I_kappa_B\|Ser_pho#pro	CATALYSIS	1	9252186,9244310,7499266,9548510,8871663
IKK _alpha_\|_pho\|active#pro ⇨ NF-_kappa_B\|active#pro	CATALYSIS	1	9252186,9244310,7499266,9548510,8871663
IKK _beta_#pro ⇨ IKK _beta_\|_pho\|active#pro	STATE_TRANSITION	0	11934728
IKK _beta_\|_pho\|active#pro ⇨ I_kappa_B\|Ser_pho#pro	CATALYSIS	1	12133833,10581243,19666608
IKK _beta_\|_pho\|active#pro ⇨ NF-_kappa_B\|_pho\|active#pro	CATALYSIS	1	10224130,15032587,12628924,9792644,12759443
IKK _beta_\|_pho\|active#pro ⇨ NF-_kappa_B\|active#pro	CATALYSIS	1	12133833,10581243,19666608
IKK _gamma_#pro ⇨ IKK _gamma_\|_ubi\|active#pro	STATE_TRANSITION	0	11057907,17562858
IKK _gamma_\|_ubi\|active#pro ⇨ IKK _beta_#pro	HETERODIMER_ASSOCIATION	0	10880512,11087742
IKK _gamma_\|_ubi\|active#pro ⇨ IKK _gamma_#pro	STATE_TRANSITION	0	22099304
IKK_epsilon_\|active#pro ⇨ IKK_epsilon_\|active+TANK+TBK1#com	HETERODIMER_ASSOCIATION	0	16125763
IKK_epsilon_\|active+TANK+TBK1#com ⇨ IRF-3\|hm2\|_pho\|active#pro	CATALYSIS	1	15210742
IKK_epsilon_\|active+TANK+TBK1#com ⇨ IRF-7\|_pho\|active#pro	CATALYSIS	1	16612387
IKK_epsilon_\|active+TANK+TBK1#com ⇨ I_kappa_B\|Ser_pho#pro	CATALYSIS	1	12133833,10581243,19666608
IKK_epsilon_\|active+TANK+TBK1#com ⇨ NF-_kappa_B\|active#pro	CATALYSIS	1	12133833,10581243,19666608
IL-1#pro ⇨ IL-1+IL-1R1+IL-1RAP#com	HETERODIMER_ASSOCIATION	0	1826128
IL-1+IL-1R1+IL-1RAP#com ⇨ IRAK1\|_pho+IRAK2+MyD88\|hm2+TRAF6\|K63_ubi\|_pho+Tollip\|_pho#com	KNOWN_TRANSITION_OMITTED	0	9426216
IL-10+IL-10 R1\|_pho+IL-10 R2\|_pho+Jak1\|_pho\|active+Tyk2\|_pho\|active#com ⇨ STAT1_alpha_\|hm2\|Y701_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	7543512,7574495,8830676
IL-10+IL-10 R1\|_pho+IL-10 R2\|_pho+Jak1\|_pho\|active+Tyk2\|_pho\|active#com ⇨ STAT3\|hm2\|Y705_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	7543512,7574495,8830676
IL-10+IL-10 R1\|_pho+IL-10 R2\|_pho+Jak1\|_pho\|active+Tyk2\|_pho\|active#com ⇨ STAT5\|hm2\|Y_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	8830676
IL-11+IL-11R_alpha_+IL-11R_beta_+gp130\|_pho#com ⇨ I_kappa_B\|Ser_pho#pro	INHIBITION	-1	9252186,9244310,7499266,9548510,8871663
IL-11+IL-11R_alpha_+IL-11R_beta_+gp130\|_pho#com ⇨ NF-_kappa_B\|active#pro	INHIBITION	-1	9252186,9244310,7499266,9548510,8871663
IL-12 R _beta_1\|_pho+IL-12 R _beta_2\|_pho+IL-12 p35+IL-12 p40+Jak2\|_pho\|active+Tyk2\|_pho\|active#com ⇨ STAT1_alpha_\|hm2\|Y701_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	12563297
IL-12 R _beta_1\|_pho+IL-12 R _beta_2\|_pho+IL-12 p35+IL-12 p40+Jak2\|_pho\|active+Tyk2\|_pho\|active#com ⇨ STAT3\|hm2\|Y705_pho\|active+STAT4\|hm2\|Y_pho\|active#com	KNOWN_TRANSITION_OMITTED	0	12563297,7722452
IL-12 R _beta_1\|_pho+IL-12 R _beta_2\|_pho+IL-12 p35+IL-12 p40+Jak2\|_pho\|active+Tyk2\|_pho\|active#com ⇨ STAT4\|hm2\|Y_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	7638186,12563297
IL-12 R _beta_1\|_pho+IL-12 R _beta_2\|_pho+IL-12 p35+IL-12 p40+Jak2\|_pho\|active+Tyk2\|_pho\|active#com ⇨ STAT5\|hm2\|Y_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	12563297,23219158
IL-12 p35#pro ⇨ IL-12 p35+IL-12 p40#com	HETERODIMER_ASSOCIATION	0	8557999
IL-12 p40#pro ⇨ IL-12 p35+IL-12 p40#com	HETERODIMER_ASSOCIATION	0	8557999
IL-12 p40#pro ⇨ IL-12 p40+IL-23 p19#com	HETERODIMER_ASSOCIATION	0	11114383
IL-13+IL-13R_alpha_1+IL-4 R_alpha_\|_pho+Jak2\|_pho\|active+Tyk2\|_pho\|active#com ⇨ STAT6\|hm2\|Y_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	12569150
IL-13+IL-13R_alpha_2#com ⇨ STAT6\|hm2\|Y_pho\|active#pro	INHIBITION	-1	12569150
IL-17F+IL-17RA+IL-17RC#com ⇨ ERK\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	24942687
IL-17F+IL-17RA+IL-17RC#com ⇨ JNK\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	24942687
IL-17F+IL-17RA+IL-17RC#com ⇨ NF-_kappa_B\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	24942687
IL-17F+IL-17RA+IL-17RC#com ⇨ p38\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	24942687
IL-18+IL-18 R_alpha_+IL-18 R_beta_#com ⇨ ERK\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	22289858
IL-18+IL-18 R_alpha_+IL-18 R_beta_#com ⇨ IRAK1\|_pho\|active+IRAK4\|_pho\|active+MyD88\|hm2+TRAF6\|K63_ubi\|_pho#com	KNOWN_TRANSITION_OMITTED	0	22289858
IL-18+IL-18 R_alpha_+IL-18 R_beta_#com ⇨ JNK\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	22289858
IL-18+IL-18 R_alpha_+IL-18 R_beta_#com ⇨ p38\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	22289858
IL-1R1#pro ⇨ IL-1+IL-1R1+IL-1RAP#com	HETERODIMER_ASSOCIATION	0	1826128
IL-1RA#pro ⇨ IL-1+IL-1R1+IL-1RAP#com	INHIBITION	-1	1826128
IL-1RAP#pro ⇨ IL-1+IL-1R1+IL-1RAP#com	HETERODIMER_ASSOCIATION	0	1826128
IL-21+IL-21R+Jak1\|_pho\|active+Jak3\|_pho\|active+_gamma_c\|_pho#com ⇨ ERK\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	24574581
IL-21+IL-21R+Jak1\|_pho\|active+Jak3\|_pho\|active+_gamma_c\|_pho#com ⇨ STAT1_alpha_\|hm2\|Y701_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	17234735
IL-21+IL-21R+Jak1\|_pho\|active+Jak3\|_pho\|active+_gamma_c\|_pho#com ⇨ STAT3\|hm2\|Y705_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	17234735
IL-21+IL-21R+Jak1\|_pho\|active+Jak3\|_pho\|active+_gamma_c\|_pho#com ⇨ STAT5\|hm2\|Y_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	12093291,17234735
IL-23 p19#pro ⇨ IL-12 p40+IL-23 p19#com	HETERODIMER_ASSOCIATION	0	11114383
IL-4 R_alpha_#pro ⇨ IL-4 R_alpha_\|_ubi#pro	STATE_TRANSITION	0	24251647
IL-4+IL-4 R_alpha_\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+Jak3\|_pho\|active+_gamma_c\|_pho#com ⇨ STAT3\|hm2\|Y705_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	23124025
IL-4+IL-4 R_alpha_\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+Jak3\|_pho\|active+_gamma_c\|_pho#com ⇨ STAT5\|hm2\|Y_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	19543225
IL-4+IL-4 R_alpha_\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+Jak3\|_pho\|active+_gamma_c\|_pho#com ⇨ STAT6\|hm2\|Y_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	23124025,23219158
IL-6+IL-6 R\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+Tyk2\|_pho\|active+gp130\|_pho#com ⇨ SHP2\|active#pro	CATALYSIS	1	9794795
IL-6+IL-6 R\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+Tyk2\|_pho\|active+gp130\|_pho#com ⇨ STAT1\|hm2\|Y701_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	15032587
IL-6+IL-6 R\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+Tyk2\|_pho\|active+gp130\|_pho#com ⇨ STAT3\|hm2\|Y705_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	7579387,23219158,15032587,9388184
IPS-1#pro ⇨ IPS-1+MDA-5#com	HETERODIMER_ASSOCIATION	0	16309964
IPS-1#pro ⇨ IPS-1+RIG-I#com	HETERODIMER_ASSOCIATION	0	16309964
IPS-1+MDA-5#com ⇨ IKK _beta_\|_pho\|active#pro	CATALYSIS	1	11460167,16125763
IPS-1+MDA-5#com ⇨ IKK_epsilon_\|active+TANK+TBK1#com	CATALYSIS	1	16125763
IPS-1+RIG-I#com ⇨ IKK _beta_\|_pho\|active#pro	CATALYSIS	1	11460167,16125763
IPS-1+RIG-I#com ⇨ IKK_epsilon_\|active+TANK+TBK1#com	CATALYSIS	1	16125763
IP_3#sim ⇨ IP_3R\|active#pro	CATALYSIS	1	17429043,1847804
IP_3R#pro ⇨ IP_3R\|active#pro	STATE_TRANSITION	0	17429043,1847804
IRAK1#pro ⇨ IRAK1+IRAK4\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	12538665
IRAK1+IRAK4\|_pho\|active#com ⇨ IRAK1\|_pho\|active+IRAK4\|_pho\|active#com	STATE_TRANSITION	0	12860525,23219158
IRAK1\|_pho+IRAK2+MyD88\|hm2+TRAF6\|K63_ubi\|_pho+Tollip\|_pho#com ⇨ ERK\|_pho\|active#pro	CATALYSIS	1	1411546,23219158,19587381,11585703
IRAK1\|_pho+IRAK2+MyD88\|hm2+TRAF6\|K63_ubi\|_pho+Tollip\|_pho#com ⇨ IKK _alpha_\|_pho\|active#pro	CATALYSIS	1	9008162,22289858,9346485,24115947
IRAK1\|_pho+IRAK2+MyD88\|hm2+TRAF6\|K63_ubi\|_pho+Tollip\|_pho#com ⇨ IKK _beta_\|_pho\|active#pro	CATALYSIS	1	11934728
IRAK1\|_pho+IRAK2+MyD88\|hm2+TRAF6\|K63_ubi\|_pho+Tollip\|_pho#com ⇨ PI3K\|active#pro	CATALYSIS	1	10373529,23219158
IRAK1\|_pho+IRAK2+MyD88\|hm2+TRAF6\|K63_ubi\|_pho+Tollip\|_pho#com ⇨ PKC_zeta_\|active#pro	CATALYSIS	1	10224130
IRAK1\|_pho\|active#pro ⇨ TAB2\|_pho#pro	CATALYSIS	1	11518704
IRAK1\|_pho\|active#pro ⇨ TAK1\|_pho\|active#pro	CATALYSIS	1	11518704,8638164
IRAK1\|_pho\|active#pro ⇨ TRAF6\|_pho#pro	CATALYSIS	1	8837778,11518704
IRAK1\|_pho\|active+IRAK4\|_pho\|active#com ⇨ IRAK1\|_pho\|active#pro	DISSOCIATION	0	12150927
IRAK1\|_pho\|active+IRAK4\|_pho\|active#com ⇨ IRAK4\|_pho\|active#pro	DISSOCIATION	0	12150927
IRAK1\|_pho\|active+IRAK4\|_pho\|active+MyD88\|hm2+TRAF6\|K63_ubi\|_pho#com ⇨ IKK _alpha_\|_pho\|active#pro	CATALYSIS	1	9008162,22289858,9346485,24115947
IRAK1\|_pho\|active+IRAK4\|_pho\|active+MyD88\|hm2+TRAF6\|K63_ubi\|_pho#com ⇨ NIK\|active#pro	CATALYSIS	1	22289858
IRAK1\|_pho\|active+IRAK4\|_pho\|active+MyD88\|hm2+TRAF6\|K63_ubi\|_pho#com ⇨ PI3K\|active#pro	CATALYSIS	1	22289858
IRAK3#pro ⇨ IRAK1\|_pho\|active#pro	INHIBITION	-1	12150927
IRAK3#pro ⇨ IRAK1\|_pho\|active+IRAK4\|_pho\|active#com	INHIBITION	-1	12860525,23219158
IRAK3#pro ⇨ IRAK4\|_pho\|active#pro	INHIBITION	-1	12150927
IRAK4#pro ⇨ IRAK4\|_pho\|active#pro	STATE_TRANSITION	0	12538665
IRAK4\|_pho\|active#pro ⇨ IRAK1+IRAK4\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	12538665
IRAK4\|_pho\|active#pro ⇨ IRAK1\|_pho\|active+IRAK4\|_pho\|active#com_1	CATALYSIS	1	12860525,23219158
IRAK4\|_pho\|active#pro ⇨ Tollip\|_pho#pro	CATALYSIS	1	10854325
IRF-1\|active#pro ⇨ IRF-1\|active+IRF-8\|active#com	HETERODIMER_ASSOCIATION	0	19720760
IRF-1\|hm2#pro ⇨ FasL CD178#pro	BRIDGED:CATALYSIS+TRANSLATION	1	12655294
IRF-1\|hm2#pro ⇨ IFN-_beta_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17399883,10215868,18433497,18332133,17273999
IRF-1\|hm2#pro ⇨ IL-12 p35#pro	BRIDGED:CATALYSIS+TRANSLATION	1	14568984,17924060,15811878,23630228
IRF-1\|hm2#pro ⇨ iNOS#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
IRF-2#pro ⇨ FasL CD178#pro	BRIDGED:CATALYSIS+TRANSLATION	1	12655294
IRF-2#pro ⇨ iNOS#pro	BRIDGED:INHIBITION+TRANSLATION	-1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
IRF-3#pro ⇨ IRF-3\|hm2\|_pho\|active#pro	STATE_TRANSITION	0	15210742
IRF-3\|active#pro ⇨ IRF-3\|active+IRF-5\|K63_ubi\|active#com	HETERODIMER_ASSOCIATION	0	18433497
IRF-3\|active+IRF-5\|K63_ubi\|active#com ⇨ IFN-_alpha_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	18824541,17399883,18433497,18332133
IRF-3\|active+IRF-5\|K63_ubi\|active#com ⇨ IFN-_beta_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17399883,10215868,18433497,18332133,17273999
IRF-3\|hm2\|_pho\|active#pro ⇨ CCL2#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22973511,19859064
IRF-3\|hm2\|_pho\|active#pro ⇨ IFN-_alpha_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	18824541,17399883,18433497,18332133
IRF-3\|hm2\|_pho\|active#pro ⇨ IFN-_beta_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17399883,10215868,18433497,18332133,17273999
IRF-3\|hm2\|_pho\|active#pro ⇨ ISG#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17399883,21498520
IRF-5#pro ⇨ IRF-5\|K63_ubi\|active#pro	STATE_TRANSITION	0	18824541,19786094,15665823
IRF-5#pro ⇨ IRF-5\|_pho#pro	STATE_TRANSITION	0	19786094
IRF-5\|K63_ubi\|active#pro ⇨ IRF-3\|active+IRF-5\|K63_ubi\|active#com	HETERODIMER_ASSOCIATION	0	18433497
IRF-5\|K63_ubi\|active#pro ⇨ IRF-5\|K63_ubi\|active+IRF-7\|active#com	HETERODIMER_ASSOCIATION	0	18433497
IRF-5\|K63_ubi\|active+IRF-7\|active#com ⇨ IFN-_alpha_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	18824541,17399883,18433497,18332133
IRF-5\|K63_ubi\|active+IRF-7\|active#com ⇨ IFN-_beta_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17399883,10215868,18433497,18332133,17273999
IRF-5\|hm2\|K63_ubi\|active#pro ⇨ IFN-_alpha_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	18824541,17399883,18433497,18332133
IRF-7#pro ⇨ IRF-7\|_pho\|active#pro	STATE_TRANSITION	0	16612387
IRF-7\|active#pro ⇨ IRF-5\|K63_ubi\|active+IRF-7\|active#com	HETERODIMER_ASSOCIATION	0	18433497
IRF-7\|hm2\|_pho\|active#pro ⇨ IFN-_alpha_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	18824541,17399883,18433497,18332133
IRF-7\|hm2\|_pho\|active#pro ⇨ IFN-_beta_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17399883,10215868,18433497,18332133,17273999
IRF-7\|hm2\|_pho\|active#pro ⇨ ISG#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17399883,21498520
IRF-8\|active#pro ⇨ IRF-1\|active+IRF-8\|active#com	HETERODIMER_ASSOCIATION	0	19720760
IRF-9#pro ⇨ IRF-9+STAT1\|hm2\|Y701_pho\|active+STAT2\|Y689_pho\|active#com	HETERODIMER_ASSOCIATION	0	24498542,8197134
IRF-9+STAT1\|hm2\|Y701_pho\|S727_pho\|active+STAT2\|Y689_pho\|active#com ⇨ 2',5'-OAS#pro	BRIDGED:CATALYSIS+TRANSLATION	1	2538838
IRF-9+STAT1\|hm2\|Y701_pho\|S727_pho\|active+STAT2\|Y689_pho\|active#com ⇨ IFN-_gamma_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8700208,9834094,1602132,23630228
IRF-9+STAT1\|hm2\|Y701_pho\|S727_pho\|active+STAT2\|Y689_pho\|active#com ⇨ IRF-1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8144663,23326354,8621447,11310846
IRF-9+STAT1\|hm2\|Y701_pho\|S727_pho\|active+STAT2\|Y689_pho\|active#com ⇨ ISG#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17399883,21498520
IRF-9+STAT1\|hm2\|Y701_pho\|S727_pho\|active+STAT2\|Y689_pho\|active#com ⇨ c-fos#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7709430,8912180,2452846,21385848
IRS1#pro ⇨ IRS1\|_pho\|active#pro	STATE_TRANSITION	0	8550573
IRS2#pro ⇨ IRS2\|_pho\|active#pro	STATE_TRANSITION	0	8550573
IRS2\|_pho\|active#pro ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,9096689,2198577,6610834,7534287
IRS2\|_pho\|active#pro ⇨ PI3K\|active#pro	CATALYSIS	1	1380456,10805725,23219158,22544939,15292195,11289110,11585703,1370584
I_kappa_B+NF-_kappa_B#com ⇨ I_kappa_B\|Ser_pho#pro	STATE_TRANSITION	0	9252186,9244310,7499266,9548510,8871663
I_kappa_B+NF-_kappa_B#com ⇨ NF-_kappa_B\|active#pro	STATE_TRANSITION	0	9252186,9244310,7499266,9548510,8871663
Interleukin+Receptor subunit_space__alpha_\|active+Receptor subunit_space__beta_\|active+Signaling subunit\|active#com ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,9096689,2198577,6610834,7534287
Interleukin+Receptor subunit_space__alpha_\|active+Receptor subunit_space__beta_\|active+Signaling subunit\|active#com ⇨ PI3K\|active#pro	CATALYSIS	1	1380456,10805725,23219158,22544939,15292195,11289110,11585703,1370584
Interleukin+Receptor subunit_space__alpha_\|active+Receptor subunit_space__beta_\|active+Signaling subunit\|active#com ⇨ c-Src\|_pho\|active#pro	CATALYSIS	1	6283105
JNK#pro ⇨ JNK\|_pho\|active#pro	STATE_TRANSITION	0	7839144
JNK\|_pho\|active#pro ⇨ AP1\|_pho\|active#pro	CATALYSIS	1	8137421,8912180
JNK\|_pho\|active#pro ⇨ ATF-2\|_pho\|active#pro	CATALYSIS	1	7824938,7535770,7824938
JNK\|_pho\|active#pro ⇨ ELK\|_pho\|active#pro	CATALYSIS	1	8846788,8978682
JNK\|_pho\|active#pro ⇨ Mdm2+p53\|_pho#com	CATALYSIS	1	7890669,7510706,9607138
JNK\|_pho\|active#pro ⇨ Smad6/7 (I-Smads)#pro	BRIDGED:CATALYSIS+TRANSLATION	1	9759503,10652273,9335507
JNK\|_pho\|active#pro ⇨ c-jun\|_pho\|active#pro	CATALYSIS	1	8224842
Jak1#pro ⇨ Jak1\|_pho\|active#pro	STATE_TRANSITION	0	7504784,7504785,23219158
Jak1#pro ⇨ Jak2\|_pho\|active#pro	CATALYSIS	1	7504785,23219158,15032587
Jak1#pro ⇨ Tyk2\|_pho\|active#pro	CATALYSIS	1	8055912,23219158
Jak1\|_pho\|active#pro ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+STAT1\|hm2\|Y701_pho\|active+STAT2\|Y689_pho\|active+Tyk2\|_pho\|active#com	CATALYSIS	1	7504785,7579387
Jak1\|_pho\|active#pro ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+Tyk2\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	11070173
Jak1\|_pho\|active#pro ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+Tyk2\|_pho\|active#com_1	CATALYSIS	1	11070173
Jak1\|_pho\|active#pro ⇨ IFN-_gamma_+IFNGR1\|_pho+IFNGR2\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+STAT1\|hm2\|Y701_pho\|active#com_1	CATALYSIS	1	8197455
Jak2#pro ⇨ Jak1\|_pho\|active#pro	CATALYSIS	1	7504784,7504785,23219158,15032587
Jak2#pro ⇨ Jak2\|_pho\|active#pro	STATE_TRANSITION	0	7504785,23219158,15032587
Jak2\|_pho\|active#pro ⇨ IFN-_gamma_+IFNGR1\|_pho+IFNGR2\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+STAT1\|hm2\|Y701_pho\|active#com_1	CATALYSIS	1	8197455
Jak2\|_pho\|active#pro ⇨ STAT3\|hm2\|Y705_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	8923468
Jak2\|_pho\|active#pro ⇨ STAT5\|hm2\|Y_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	10373548,23219158,15032587,7539031
Jak2\|_pho\|active+LepR\|_pho+Leptin#com ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,7508932,7513165,22685316
Jak2\|_pho\|active+LepR\|_pho+Leptin#com ⇨ STAT3\|Y705_pho\|active#pro	CATALYSIS	1	8631962,19587381,22685316
Jak2\|_pho\|active+LepR\|_pho+Leptin#com ⇨ STAT5\|Y_pho\|active#pro	CATALYSIS	1	7720707,22685316
Jak3\|_pho\|active#pro ⇨ STAT5\|hm2\|Y_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	8580378
L-arginine#sim ⇨ L-citrulline#sim	STATE_TRANSITION	0	1696255
L-arginine#sim ⇨ NADP_+#sim	STATE_TRANSITION	0	1696255
L-arginine#sim ⇨ NO#ion	STATE_TRANSITION	0	1696255
LPCAT#pro ⇨ PAF#sim	CATALYSIS	1	7055592,18285344
LPS#sim ⇨ CD14+LPS+MD-2+TLR4#com	HETERODIMER_ASSOCIATION	0	10196138
LTA_4#sim ⇨ LTB_4#sim	STATE_TRANSITION	0	3144211,6311078
LTA_4#sim ⇨ LTC_4#sim	STATE_TRANSITION	0	6311078
LTA_4H#pro ⇨ LTB_4#sim	CATALYSIS	1	3144211,6311078
LTC_4S#pro ⇨ LTC_4#sim	CATALYSIS	1	6311078
Lyn\|active#pro ⇨ FcR _gamma_\|Y_pho#pro	CATALYSIS	1	22101734,17086186
LysoPC#sim ⇨ PAF#sim	STATE_TRANSITION	0	7055592,18285344
M-CSF+M-CSFR#com ⇨ Fyn\|active#pro	CATALYSIS	1	7681396
M-CSF+M-CSFR#com ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,7508932,7513165,22685316
M-CSF+M-CSFR#com ⇨ PI3K\|active#pro	CATALYSIS	1	10805725,10473597,15646653
M-CSF+M-CSFR#com ⇨ PLC_gamma_\|active#pro	CATALYSIS	1	9312046,19587381
M-CSF+M-CSFR#com ⇨ STAT1\|Y701_pho\|active#pro	CATALYSIS	1	8378775,8631962
MALT#pro ⇨ Bcl10+CARD9\|_pho+MALT#com	HETERODIMER_ASSOCIATION	0	23523010,16862125
MAP4K5\|active#pro ⇨ MEKK1\|Thr_pho\|active#pro	CATALYSIS	1	9065412
MAPKAPK2#pro ⇨ MAPKAPK2\|_pho\|active#pro	STATE_TRANSITION	0	8666821
MAPKAPK2\|_pho\|active#pro ⇨ CREB\|_pho\|active#pro	CATALYSIS	1	9687510
MAPKAPK2\|_pho\|active#pro ⇨ SRF\|_pho\|active#pro	CATALYSIS	1	10318869
MDA-5+dsRNA#com ⇨ Caspase-1\|active#pro	CATALYSIS	1	11390368,19915568,23307811,22753929
MDA-5+dsRNA#com ⇨ IPS-1+MDA-5#com	HETERODIMER_ASSOCIATION	0	16309964
MDP+NOD2#com ⇨ CARD9\|active#pro	CATALYSIS	1	17187069
MDP+NOD2#com ⇨ RIP2\|active#pro	CATALYSIS	1	11894097,11087742
MEK#pro ⇨ MEK\|_pho\|active#pro	STATE_TRANSITION	0	1322500
MEKK1#pro ⇨ MEKK1\|Thr_pho\|active#pro	STATE_TRANSITION	0	9065412
MEKK1\|Thr_pho\|active#pro ⇨ IKK _alpha_\|_pho\|active#pro	CATALYSIS	1	9008162,22289858,9346485,24115947
MEKK1\|Thr_pho\|active#pro ⇨ MKK4\|_pho\|active#pro	CATALYSIS	1	9639556,8974401
MEKK1\|active#pro ⇨ ECSIT+MEKK1\|active+TAB1+TAB2\|_pho+TAK1\|_pho\|active+TRAF6\|K63_ubi\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	12242293,10465784
MEK\|_pho\|active#pro ⇨ ERK\|_pho\|active#pro	CATALYSIS	1	1411546,23219158,19587381,11585703
MIF#pro ⇨ TLR4#pro	BRIDGED:CATALYSIS+TRANSLATION	1	11780066
MKK3#pro ⇨ MKK3\|_pho\|active#pro	STATE_TRANSITION	0	8974401
MKK3\|_pho\|active#pro ⇨ JNK\|_pho\|active#pro	CATALYSIS	1	7839144,8621675,19043549,17187069,17348859,15032587
MKK3\|_pho\|active#pro ⇨ p38\|_pho\|active#pro	CATALYSIS	1	7839144
MKK4#pro ⇨ MKK4\|_pho\|active#pro	STATE_TRANSITION	0	9639556,8974401
MKK4\|_pho\|active#pro ⇨ JNK\|_pho\|active#pro	CATALYSIS	1	7839144
MKK4\|_pho\|active#pro ⇨ p38\|_pho\|active#pro	CATALYSIS	1	7839144,8621675,19043549,17187069,17348859,15032587,11585703
MKK6#pro ⇨ MKK6\|_pho\|active#pro	STATE_TRANSITION	0	11460167
MKK6\|_pho\|active#pro ⇨ JNK\|_pho\|active#pro	CATALYSIS	1	7839144,8621675,19043549,17187069,17348859,15032587
MKK6\|_pho\|active#pro ⇨ p38\|_pho\|active#pro	CATALYSIS	1	7839144,8621675,19043549,17187069,17348859,15032587,11585703
MNK 1/2#pro ⇨ MNK 1/2\|_pho\|active#pro	STATE_TRANSITION	0	9155017
MNK 1/2\|_pho\|active#pro ⇨ eIF4E\|_pho\|active#pro	CATALYSIS	1	15254222
MSK 1/2#pro ⇨ MSK 1/2\|_pho\|active#pro	STATE_TRANSITION	0	9687510
MSK 1/2\|_pho\|active#pro ⇨ 4EBP1\|_pho#pro	CATALYSIS	1	8633019
MSK 1/2\|_pho\|active#pro ⇨ ATF-1\|_pho\|active#pro	CATALYSIS	1	8887554
MSK 1/2\|_pho\|active#pro ⇨ CREB\|_pho\|active#pro	CATALYSIS	1	9687510
MSK 1/2\|_pho\|active#pro ⇨ NF-_kappa_B\|_pho\|active#pro	CATALYSIS	1	10224130,15032587,12628924,9792644,12759443
MSK 1/2\|_pho\|active#pro ⇨ histone H3\|Ser10_pho#pro	CATALYSIS	1	10469656
Mdm2#pro ⇨ Mdm2+p53#com	HETERODIMER_ASSOCIATION	0	1535557
Mdm2+p53#com ⇨ Mdm2+p53\|_pho#com	STATE_TRANSITION	0	7890669,7510706,9607138
Mdm2+p53#com ⇨ Mdm2+p53\|_ubi#com	STATE_TRANSITION	0	8653711
Mdm2+p53\|_pho#com ⇨ Mdm2#pro	DISSOCIATION	0	9363941,10202145,10202144
Mdm2+p53\|_pho#com ⇨ p53\|_pho\|active#pro	DISSOCIATION	0	9363941,10202145,10202144
Mdm2+p53\|_ubi#com ⇨ Mdm2#pro	DISSOCIATION	0	17369817
Mdm2+p53\|_ubi#com ⇨ p53\|_ubi#pro	DISSOCIATION	0	17369817
MyD88#pro ⇨ MyD88\|hm2+TIRAP#com	HETERODIMER_ASSOCIATION	0	15229469
MyD88#pro ⇨ MyD88\|hm2\|active#pro	STATE_TRANSITION	0	15229469
MyD88\|hm2+TIRAP#com ⇨ IRAK4\|_pho\|active#pro	CATALYSIS	1	12538665
MyD88\|hm2\|active#pro ⇨ IRAK1+IRAK4\|_pho\|active#com	CATALYSIS	1	12538665
MyD88\|hm2\|active#pro ⇨ IRAK4\|_pho\|active#pro	CATALYSIS	1	12538665
NADPH#sim ⇨ L-citrulline#sim	STATE_TRANSITION	0	1696255
NADPH#sim ⇨ NO#ion	STATE_TRANSITION	0	1696255
NF-_kappa_B\|_pho\|active#pro ⇨ A20#pro	BRIDGED:CATALYSIS+TRANSLATION	1	1381359
NF-_kappa_B\|_pho\|active#pro ⇨ CCL2#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22973511,19859064
NF-_kappa_B\|_pho\|active#pro ⇨ CCL20#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22240809
NF-_kappa_B\|_pho\|active#pro ⇨ CXCL10#pro	BRIDGED:CATALYSIS+TRANSLATION	1	11310846,8454640
NF-_kappa_B\|_pho\|active#pro ⇨ CXCL2#pro	BRIDGED:CATALYSIS+TRANSLATION	1	24280128,23024284,20671197
NF-_kappa_B\|_pho\|active#pro ⇨ CXCL8#pro	BRIDGED:CATALYSIS+TRANSLATION	1	18034886,18515182
NF-_kappa_B\|_pho\|active#pro ⇨ FasL CD178#pro	BRIDGED:CATALYSIS+TRANSLATION	1	12655294
NF-_kappa_B\|_pho\|active#pro ⇨ IFN-_alpha_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	18824541,17399883,18433497,18332133
NF-_kappa_B\|_pho\|active#pro ⇨ IFN-_beta_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17399883,10215868,18433497,18332133,17273999
NF-_kappa_B\|_pho\|active#pro ⇨ IL-10#pro	BRIDGED:CATALYSIS+TRANSLATION	1	10903771,20154735,16713974,23814099,24835395
NF-_kappa_B\|_pho\|active#pro ⇨ IL-12 p35#pro	BRIDGED:CATALYSIS+TRANSLATION	1	14568984,17924060,15811878,23630228
NF-_kappa_B\|_pho\|active#pro ⇨ IL-15#pro	BRIDGED:CATALYSIS+TRANSLATION	1	17158609
NF-_kappa_B\|_pho\|active#pro ⇨ IL-6#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22312110,2405250,2786029,15811878,23177475,18515182
NF-_kappa_B\|_pho\|active#pro ⇨ NF-_kappa_B\|_pho+PPAR_gamma_#com	HETERODIMER_ASSOCIATION	0	17277894
NF-_kappa_B\|_pho\|active#pro ⇨ NF-_kappa_B\|_pho\|active+PIAS1#com	HETERODIMER_ASSOCIATION	0	16474434
NF-_kappa_B\|_pho\|active#pro ⇨ SOCS1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	23219158,15032587,19144316,19699171
NF-_kappa_B\|_pho\|active#pro ⇨ SOCS3#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22973511,23219158,15032587,10433356,19422799,18291670,24607843
NF-_kappa_B\|_pho\|active#pro ⇨ Smad6/7 (I-Smads)#pro	BRIDGED:CATALYSIS+TRANSLATION	1	9759503,10652273,9335507
NF-_kappa_B\|_pho\|active#pro ⇨ TNF#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22312110,2181276,22147692,23177475,15811878,23630228,18515182,18291670
NF-_kappa_B\|_pho\|active#pro ⇨ iNOS#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
NF-_kappa_B\|_pho\|active#pro ⇨ miR-125b#ant	INHIBITION	-1	18515182,18291670
NF-_kappa_B\|_pho\|active#pro ⇨ miR-146a#ant	CATALYSIS	1	18515182,18291670
NF-_kappa_B\|_pho\|active#pro ⇨ miR-155#ant	CATALYSIS	1	18515182,17242365
NF-_kappa_B\|_pho\|active#pro ⇨ pro-IL-1_beta_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8413223,23630228,8943727
NF-_kappa_B\|active#pro ⇨ NF-_kappa_B\|_pho\|active#pro_1	STATE_TRANSITION	0	10224130,15032587,12628924,9792644,12759443
NFAT5#pro ⇨ FasL CD178#pro	BRIDGED:CATALYSIS+TRANSLATION	1	12655294
NFAT5#pro ⇨ IL-6#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22312110,2405250,2786029,15811878,23177475,18515182
NFAT5#pro ⇨ TNF#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22312110,2181276,22147692,23177475,15811878,23630228,18515182,18291670
NFAT5#pro ⇨ iNOS#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
NIK#pro ⇨ NIK\|active#pro	STATE_TRANSITION	0	22289858
NIK\|active#pro ⇨ IKK _alpha_\|_pho\|active#pro	CATALYSIS	1	9008162,22289858,9346485,24115947
NO#ion ⇨ HIF-1_alpha_#pro	CATALYSIS	1	21199675
NO#ion ⇨ HIF-PHD\|active#pro	INHIBITION	-1	21199675
NO#ion ⇨ iNOS#pro	BRIDGED:INHIBITION+TRANSLATION	-1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
NOD1+iE-DAP#com ⇨ RIP2\|active#pro	CATALYSIS	1	11894097,11087742
Nalp1\|active#pro ⇨ Caspase-1\|active#pro	CATALYSIS	1	11390368,19915568,23307811,22753929
Nalp3#pro ⇨ Nalp3\|active#pro	STATE_TRANSITION	0	25295542
Nalp3\|active#pro ⇨ Caspase-1\|active#pro	CATALYSIS	1	11390368,19915568,23307811,22753929
O_2#ion ⇨ L-citrulline#sim	STATE_TRANSITION	0	1696255
O_2#ion ⇨ NO#ion	STATE_TRANSITION	0	1696255
P2X_7#pro ⇨ ATP+P2X_7#com	HETERODIMER_ASSOCIATION	0	25295542
PAF#sim ⇨ PAF+PAFR#com	HETERODIMER_ASSOCIATION	0	2545780,10966465
PAF+PAFR#com ⇨ 5-lipoxygenase\|active#pro	CATALYSIS	1	2545780,19075240
PAF+PAFR#com ⇨ PLC_beta_\|active#pro	CATALYSIS	1	22012553,14617636
PAF+PAFR#com ⇨ adenylate cyclase\|active#pro	CATALYSIS	1	22012553,14617636
PAFR#pro ⇨ PAF+PAFR#com	HETERODIMER_ASSOCIATION	0	2545780,10966465
PAK#pro ⇨ PAK\|_pho\|active#pro	STATE_TRANSITION	0	8973630,22544939
PAK\|_pho\|active#pro ⇨ NF-_kappa_B\|_pho\|active#pro	CATALYSIS	1	2548081,10779525
PAK\|_pho\|active#pro ⇨ PI3K\|active#pro	CATALYSIS	1	1380456,10805725,23219158,22544939,15292195,11289110,11585703,1370584
PDGF+PDGFR#com ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,9096689,2198577,6610834,7534287
PDK1#pro ⇨ PDK1\|_pho\|active#pro	STATE_TRANSITION	0	9247112
PDK1\|_pho\|active#pro ⇨ AKT\|_pho\|active#pro	CATALYSIS	1	9094314
PGDS#pro ⇨ PGD_2#sim	CATALYSIS	1	6803534,3144211,21865441
PGD_2#sim ⇨ PGF_2_alpha_#sim	STATE_TRANSITION	0	3858278
PGES#pro ⇨ PGE_2#sim	CATALYSIS	1	6794395,6803534,3144211,21865441
PGFS#pro ⇨ PGF_2_alpha_#sim	CATALYSIS	1	6794395,6803534,18006499,21865441
PGH_2#sim ⇨ PGD_2#sim	STATE_TRANSITION	0	6803534,3144211,21865441
PGH_2#sim ⇨ PGE_2#sim	STATE_TRANSITION	0	6794395,6803534,3144211,21865441
PGH_2#sim ⇨ PGF_2_alpha_#sim	STATE_TRANSITION	0	6794395,6803534,18006499,21865441
PGH_2#sim ⇨ PGI_2#sim	STATE_TRANSITION	0	21865441
PGH_2#sim ⇨ TXA_2#sim	STATE_TRANSITION	0	6803534,1691652,21865441
PGIS#pro ⇨ PGI_2#sim	CATALYSIS	1	21865441
PI3K#pro ⇨ PI3K\|active#pro	STATE_TRANSITION	0	12792849
PI3K\|active#pro ⇨ IKK _alpha_\|_pho\|active#pro	CATALYSIS	1	9008162,22289858,9346485,24115947
PI3K\|active#pro ⇨ PIP_3#sim	CATALYSIS	1	23330955
PIAS1#pro ⇨ NF-_kappa_B\|_pho\|active+PIAS1#com	HETERODIMER_ASSOCIATION	0	16474434
PIAS1#pro ⇨ PIAS1+STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#com	HETERODIMER_ASSOCIATION	0	9724754
PIAS3#pro ⇨ PIAS3+STAT3\|hm2\|Y705_pho\|S727_pho\|active#com	HETERODIMER_ASSOCIATION	0	9388184
PIAS3#pro ⇨ STAT3\|hm2\|Y705_pho\|active#pro	INHIBITION	-1	7579387,23219158,15032587,9388184
PIP_2#sim ⇨ DAG#sim	STATE_TRANSITION	0	11395409,18787561
PIP_2#sim ⇨ IP_3#sim	STATE_TRANSITION	0	11395409,18787561
PIP_2#sim ⇨ PIP_3#sim	STATE_TRANSITION	0	23330955
PIP_3#sim ⇨ PDK1\|_pho\|active#pro	CATALYSIS	1	9247112
PIP_3#sim ⇨ PIP_2#sim	STATE_TRANSITION	0	9593664,10339565,8654924
PKA#pro ⇨ PKA\|active#pro	STATE_TRANSITION	0	4372627,9242925
PKA\|active#pro ⇨ CREB\|_pho\|active#pro	CATALYSIS	1	9687510,9242925
PKA\|active#pro ⇨ IP_3R\|active#pro	INHIBITION	-1	17429043,1847804
PKA\|active#pro ⇨ PI3K\|active#pro	CATALYSIS	1	12958648,2399454,7713890,17016431,15313431,18411281,22101734
PKA\|active#pro ⇨ PLC_beta_\|active#pro	INHIBITION	-1	8316840,12958648,23994549,15313431,18411281
PKA\|active#pro ⇨ PLD\|active#pro	INHIBITION	-1	7510960,17631865,18569866
PKC#pro ⇨ PKC\|active#pro	STATE_TRANSITION	0	12792849
PKC_alpha_\|active#pro ⇨ PKC_alpha_+PPAR_gamma_#com	HETERODIMER_ASSOCIATION	0	17277894
PKC_alpha_\|active#pro ⇨ Rac+Rap1a+gp91_phox+p22_phox+p40_phox+p47_phox+p67_phox#com	CATALYSIS	1	22544939,18094534,17277894
PKC_delta_#pro ⇨ PKC_delta_\|_pho\|active#pro	STATE_TRANSITION	0	22544939
PKC_delta_#pro ⇨ PKC_delta_\|active#pro	STATE_TRANSITION	0	23523010
PKC_delta_\|_pho\|active#pro ⇨ PAK\|_pho\|active#pro	CATALYSIS	1	8973630,22544939
PKC_delta_\|active#pro ⇨ CARD9\|_pho#pro	CATALYSIS	1	23523010,16862125
PKC_delta_\|active#pro ⇨ IRF-1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8144663,23326354,8621447,11310846
PKC_zeta_#pro ⇨ PKC_zeta_\|active#pro	STATE_TRANSITION	0	10224130
PKC_zeta_\|active#pro ⇨ NF-_kappa_B\|_pho\|active#pro	CATALYSIS	1	10224130,15032587,12628924,9792644,12759443
PKC\|active#pro ⇨ PLD\|active#pro	CATALYSIS	1	7510960,17631865,18569866
PKC\|active#pro ⇨ Raf\|active#pro	CATALYSIS	1	15040586
PLA_2#pro ⇨ LysoPC#sim	CATALYSIS	1	3102603
PLA_2#pro ⇨ arachidonic acid#sim	CATALYSIS	1	3102603
PLC_beta_#pro ⇨ PLC_beta_\|active#pro	STATE_TRANSITION	0	8316840,12958648,23994549,15313431,18411281
PLC_beta_\|active#pro ⇨ DAG#sim	CATALYSIS	1	11395409,18787561
PLC_beta_\|active#pro ⇨ IP_3#sim	CATALYSIS	1	11395409,18787561
PLC_gamma_#pro ⇨ PLC_gamma_\|active#pro	STATE_TRANSITION	0	12792849
PLC_gamma_\|active#pro ⇨ DAG#sim	CATALYSIS	1	11395409,18787561
PLC_gamma_\|active#pro ⇨ ERK\|_pho\|active#pro	CATALYSIS	1	1411546,23219158,19587381,11585703
PLC_gamma_\|active#pro ⇨ IP_3#sim	CATALYSIS	1	11395409,18787561
PLD#pro ⇨ PLD\|active#pro	STATE_TRANSITION	0	7510960,17631865,18569866
PLK3#pro ⇨ HIF-1_alpha_\|Ser_pho#pro	CATALYSIS	1	20889502,17325032
PP4#pro ⇨ TRAF6\|K63_ubi\|_pho\|active#pro	INHIBITION	-1	11057907,18634786
PPAR_gamma_#pro ⇨ AP1\|_pho+PPAR_gamma_#com	HETERODIMER_ASSOCIATION	0	17277894
PPAR_gamma_#pro ⇨ CBP+PPAR_gamma_#com	HETERODIMER_ASSOCIATION	0	17277894,10075656
PPAR_gamma_#pro ⇨ NF-_kappa_B\|_pho+PPAR_gamma_#com	HETERODIMER_ASSOCIATION	0	17277894
PPAR_gamma_#pro ⇨ PKC_alpha_+PPAR_gamma_#com	HETERODIMER_ASSOCIATION	0	17277894
PPAR_gamma_#pro ⇨ PPAR_gamma_+RXR#com	HETERODIMER_ASSOCIATION	0	1324435
PPAR_gamma_#pro ⇨ p300 HAT#com	HETERODIMER_ASSOCIATION	0	10075656
PTEN\|active#pro ⇨ PIP_2#sim	CATALYSIS	1	9593664,10339565,8654924
PU.1#pro ⇨ PU.1\|Ser_pho\|active#pro	STATE_TRANSITION	0	8691150
PU.1\|Ser_pho\|active#pro ⇨ CAP-18 LL-37#pro	BRIDGED:CATALYSIS+TRANSLATION	1	24246949
PU.1\|Ser_pho\|active#pro ⇨ GM-CSFR_alpha_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7565736
PU.1\|Ser_pho\|active#pro ⇨ M-CSFR#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8691150
Phospholipids#sim ⇨ LysoPC#sim	DISSOCIATION	0	3102603
Phospholipids#sim ⇨ arachidonic acid#sim	DISSOCIATION	0	3102603
RIG-I+dsRNA+ssRNA#com ⇨ Caspase-1\|active#pro	CATALYSIS	1	11390368,19915568,23307811,22753929
RIG-I+dsRNA+ssRNA#com ⇨ IPS-1+RIG-I#com	HETERODIMER_ASSOCIATION	0	16309964
RIP+Raf+TRAF1+TRAF2+cFLIP_L#com ⇨ ERK\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	15491504
RIP+Raf+TRAF1+TRAF2+cFLIP_L#com ⇨ NF-_kappa_B\|_pho\|active#pro	KNOWN_TRANSITION_OMITTED	0	15491504
RIP+TRADD+TRAF2#com ⇨ ASK1\|active#pro	CATALYSIS	1	9774977
RIP+TRADD+TRAF2#com ⇨ IKK _beta_\|_pho\|active#pro	CATALYSIS	1	11934728
RIP+TRADD+TRAF2#com ⇨ NIK\|active#pro	CATALYSIS	1	10391945
RIP+TRADD+TRAF2#com ⇨ PKC_zeta_\|active#pro	CATALYSIS	1	10224130
RIP+TRADD+TRAF2#com ⇨ TANK\|active#pro	CATALYSIS	1	16712718
RIP2#pro ⇨ RIP2\|active#pro	STATE_TRANSITION	0	11894097,11087742
RIP2\|active#pro ⇨ IKK _beta_#pro	CATALYSIS	1	10880512,11087742
RIP2\|active#pro ⇨ IKK _gamma_\|_ubi\|active#pro	CATALYSIS	1	11057907,17562858
RIP2\|active#pro ⇨ JNK\|_pho\|active#pro	CATALYSIS	1	7839144,8621675,19043549,17187069,17348859,15032587
RIP2\|active#pro ⇨ p38\|_pho\|active#pro	CATALYSIS	1	7839144,8621675,19043549,17187069,17348859,15032587,11585703
RXR#pro ⇨ PPAR_gamma_+RXR#com	HETERODIMER_ASSOCIATION	0	1324435
Rac#pro ⇨ Rac\|active#pro	STATE_TRANSITION	0	15292195
Rac\|active#pro ⇨ PAK\|_pho\|active#pro	CATALYSIS	1	8973630,22544939
Rac\|active#pro ⇨ Rac+Rap1a+gp91_phox+p22_phox+p40_phox+p47_phox+p67_phox#com	HETERODIMER_ASSOCIATION	0	22544939,18094534,17277894
Raf#pro ⇨ Raf\|active#pro	STATE_TRANSITION	0	15040586
Raf\|active#pro ⇨ MEK\|_pho\|active#pro	CATALYSIS	1	1322500
Rap1a+gp91_phox+p22_phox#com ⇨ Rac+Rap1a+gp91_phox+p22_phox+p40_phox+p47_phox+p67_phox#com	HETERODIMER_ASSOCIATION	0	22544939,18094534,17277894
RasGAP#pro ⇨ p21Ras#pro	CATALYSIS	1	2833817
RasGEF#pro ⇨ p21Ras\|active#pro	CATALYSIS	1	7786285,8607978,8479530,8599089
Rheb#pro ⇨ Rheb\|active#pro	STATE_TRANSITION	0	15094766
Rheb\|active#pro ⇨ mTOR\|_pho\|active#pro	CATALYSIS	1	10910062,24121838,15094766
SHIP-1#pro ⇨ PIP_2#sim	CATALYSIS	1	9593664,10339565,8654924
SHP1#pro ⇨ SHP1\|active#pro	STATE_TRANSITION	0	9743328
SHP1\|active#pro ⇨ Tyk2#pro	CATALYSIS	1	7629131
SHP2#pro ⇨ SHP2\|active#pro	STATE_TRANSITION	0	7522233,19587381
SHP2\|active#pro ⇨ STAT1_alpha_\|hm2#pro	CATALYSIS	1	9497348
SOCS1#pro ⇨ IRAK1\|_pho\|active+IRAK4\|_pho\|active#com	INHIBITION	-1	12860525,23219158
SOCS1#pro ⇨ JNK\|_pho\|active#pro	INHIBITION	-1	7839144,8621675,19043549,17187069,17348859,15032587
SOCS1#pro ⇨ Jak1\|_pho\|active#pro	INHIBITION	-1	7504784,7504785,23219158
SOCS1#pro ⇨ Jak2\|_pho\|active#pro	INHIBITION	-1	7504785,23219158,15032587
SOCS1#pro ⇨ NF-_kappa_B\|_pho\|active#pro	INHIBITION	-1	10224130,15032587,12628924,9792644,12759443
SOCS1#pro ⇨ STAT3\|hm2\|Y705_pho\|active#pro	INHIBITION	-1	7579387,23219158,15032587,9388184
SOCS1#pro ⇨ STAT4\|hm2\|Y_pho\|active#pro	INHIBITION	-1	7638186,12563297
SOCS1#pro ⇨ STAT5\|hm2\|Y_pho\|active#pro	INHIBITION	-1	10373548,23219158,15032587,7539031
SOCS1#pro ⇨ STAT6\|hm2\|Y_pho\|active#pro	INHIBITION	-1	23124025,23219158
SOCS1#pro ⇨ Tyk2\|_pho\|active#pro	INHIBITION	-1	8055912,23219158
SOCS1#pro ⇨ p38\|_pho\|active#pro	INHIBITION	-1	7839144,8621675,19043549,17187069,17348859,15032587,11585703
SOCS2#pro ⇨ STAT5\|hm2\|Y_pho\|active#pro	INHIBITION	-1	10373548,23219158,15032587,7539031
SOCS3#pro ⇨ Jak1\|_pho\|active#pro	INHIBITION	-1	7504784,7504785,23219158
SOCS3#pro ⇨ Jak2\|_pho\|active#pro	INHIBITION	-1	7504785,23219158,15032587
SOCS3#pro ⇨ STAT3\|hm2\|Y705_pho\|active#pro	INHIBITION	-1	7579387,23219158,15032587,9388184
SOCS3#pro ⇨ STAT4\|hm2\|Y_pho\|active#pro	INHIBITION	-1	7638186,12563297
SOCS3#pro ⇨ STAT5\|hm2\|Y_pho\|active#pro	INHIBITION	-1	10373548,23219158,15032587,7539031
SOCS3#pro ⇨ Tyk2\|_pho\|active#pro	INHIBITION	-1	8055912,23219158
SOCS5#pro ⇨ STAT3\|hm2\|Y705_pho\|active#pro	INHIBITION	-1	7579387,23219158,15032587,9388184
SOCS5#pro ⇨ STAT6\|hm2\|Y_pho\|active#pro	INHIBITION	-1	23124025,23219158
SOCS6#pro ⇨ ERK\|_pho\|active#pro	INHIBITION	-1	1411546,23219158,19587381,11585703
SOCS6#pro ⇨ PI3K\|active#pro	INHIBITION	-1	10373529,23219158
SOCS7#pro ⇨ STAT3\|hm2\|Y705_pho\|active#pro	INHIBITION	-1	7579387,23219158,15032587,9388184
SOCS7#pro ⇨ STAT5\|hm2\|Y_pho\|active#pro	INHIBITION	-1	10373548,23219158,15032587,7539031
SOS#pro ⇨ Grb2\|active+SOS\|active+Shc\|active#com	HETERODIMER_ASSOCIATION	0	8479536,7508932,7513165,22685316
SRF#pro ⇨ SRF\|_pho\|active#pro	STATE_TRANSITION	0	10318869
SRF\|_pho\|active#pro ⇨ c-fos#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7709430,8912180,2452846,21385848
STAT1#pro ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+STAT1\|hm2\|Y701_pho\|active+STAT2\|Y689_pho\|active+Tyk2\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	7504785,7579387
STAT1#pro ⇨ IFN-_gamma_+IFNGR1\|_pho+IFNGR2\|_pho+Jak1\|_pho\|active+Jak2\|_pho\|active+STAT1\|hm2\|Y701_pho\|active#com	HETERODIMER_ASSOCIATION	0	8197455
STAT1#pro ⇨ STAT1\|Y701_pho\|active#pro	STATE_TRANSITION	0	8378775,8631962
STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro ⇨ CXCL10#pro	BRIDGED:CATALYSIS+TRANSLATION	1	11310846,8454640
STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro ⇨ CXCL2#pro	BRIDGED:CATALYSIS+TRANSLATION	1	24280128,23024284,20671197
STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro ⇨ IFN-_gamma_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8700208,9834094,1602132,23630228
STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro ⇨ IL-6#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22312110,2405250,2786029,15811878,23177475,18515182
STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro ⇨ IRF-1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8144663,23326354,8621447,11310846
STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro ⇨ PIAS1+STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#com	HETERODIMER_ASSOCIATION	0	9724754
STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro ⇨ SOCS1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	23219158,15032587,19144316,19699171
STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro ⇨ STAT1_alpha_\|hm2#pro	STATE_TRANSITION	0	9497348
STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro ⇨ c-fos#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7709430,8912180,2452846,21385848
STAT1_alpha_\|hm2\|Y701_pho\|active#pro ⇨ STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro	STATE_TRANSITION	0	8557638,15266021,7543024
STAT1\|Y701_pho\|active#pro ⇨ IRF-9+STAT1\|hm2\|Y701_pho\|active+STAT2\|Y689_pho\|active#com	HETERODIMER_ASSOCIATION	0	24498542,8197134
STAT1\|Y701_pho\|active#pro ⇨ STAT1\|hm2\|Y701_pho\|active#pro	STATE_TRANSITION	0	7510216
STAT2#pro ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+STAT1\|hm2\|Y701_pho\|active+STAT2\|Y689_pho\|active+Tyk2\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	7504785,7579387
STAT2\|S287_pho\|Y689_pho\|active#pro ⇨ ISG#pro	BRIDGED:INHIBITION+TRANSLATION	-1	17399883,21498520
STAT2\|Y689_pho\|active#pro ⇨ IRF-9+STAT1\|hm2\|Y701_pho\|active+STAT2\|Y689_pho\|active#com	HETERODIMER_ASSOCIATION	0	24498542,8197134
STAT3#pro ⇨ STAT3\|Y705_pho\|active#pro	STATE_TRANSITION	0	8631962,19587381,22685316
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ CCL2#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22973511,19859064
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ CXCL2#pro	BRIDGED:CATALYSIS+TRANSLATION	1	24280128,23024284,20671197
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ IL-10#pro	BRIDGED:CATALYSIS+TRANSLATION	1	10903771,20154735,16713974,23814099,24835395
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ IL-1RA#pro	BRIDGED:CATALYSIS+TRANSLATION	1	15218058,8757327
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ IL-6#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22312110,2405250,2786029,15811878,23177475,18515182
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ PIAS3+STAT3\|hm2\|Y705_pho\|S727_pho\|active#com	HETERODIMER_ASSOCIATION	0	9388184
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ SOCS1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	23219158,15032587,19144316,19699171
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ SOCS3#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22973511,23219158,15032587,10433356,19422799,18291670,24607843
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ c-fos#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7709430,8912180,2452846,21385848
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ iNOS#pro	BRIDGED:INHIBITION+TRANSLATION	-1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro ⇨ p21 CIP1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	9694869,8242752,18978791
STAT3\|hm2\|Y705_pho\|active#pro ⇨ STAT3\|hm2\|Y705_pho\|S727_pho\|active#pro	STATE_TRANSITION	0	9343414,7543024
STAT4\|hm2\|Y_pho\|S721_pho\|active#pro ⇨ IFN-_gamma_#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8700208,9834094,1602132,23630228
STAT4\|hm2\|Y_pho\|S721_pho\|active#pro ⇨ IRF-1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8144663,23326354,8621447,11310846
STAT5#pro ⇨ STAT5\|Y_pho\|active#pro	STATE_TRANSITION	0	7720707,22685316
STAT5\|hm2\|Y_pho\|S_pho\|active#pro ⇨ SOCS1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	23219158,15032587,19144316,19699171
STAT6\|hm2\|Y_pho\|S756_pho\|active#pro ⇨ IL-1RA#pro	BRIDGED:CATALYSIS+TRANSLATION	1	15218058,8757327
STAT6\|hm2\|Y_pho\|S756_pho\|active#pro ⇨ Jmjd3#pro	BRIDGED:CATALYSIS+TRANSLATION	1	20856215
STAT6\|hm2\|Y_pho\|S756_pho\|active#pro ⇨ SOCS3#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22973511,23219158,15032587,10433356,19422799,18291670,24607843
STUB1#pro ⇨ IL-4 R_alpha_\|_ubi#pro	CATALYSIS	1	24251647
SUMO#pro ⇨ HIF-1_alpha_+SUMO#com	HETERODIMER_ASSOCIATION	0	17981124
Senp1#pro ⇨ Senp1\|active#pro	STATE_TRANSITION	0	17981124
Senp1\|active#pro ⇨ HIF-1_alpha_#pro	CATALYSIS	1	17981124
Senp1\|active#pro ⇨ SUMO#pro	CATALYSIS	1	17981124
Shc#pro ⇨ Grb2\|active+SOS\|active+Shc\|active#com	HETERODIMER_ASSOCIATION	0	8479536,7508932,7513165,22685316
Smad2/3 (R-Smads)#pro ⇨ Smad2/3 (R-Smads)\|_pho\|active#pro	STATE_TRANSITION	0	9311995,9346966,9346908
Smad2/3 (R-Smads)#pro ⇨ Smad2/3 (R-Smads)\|_ubi+Smurf2#com	HETERODIMER_ASSOCIATION	0	11016919
Smad2/3 (R-Smads)\|_pho+Smad4 (Co-Smad)#com ⇨ IL-12 p35#pro	BRIDGED:INHIBITION+TRANSLATION	-1	14568984,17924060,15811878,23630228
Smad2/3 (R-Smads)\|_pho+Smad4 (Co-Smad)#com ⇨ Smad6/7 (I-Smads)#pro	BRIDGED:CATALYSIS+TRANSLATION	1	9759503,10652273,9335507
Smad2/3 (R-Smads)\|_pho\|active#pro ⇨ Smad2/3 (R-Smads)\|_pho+Smad4 (Co-Smad)#com	HETERODIMER_ASSOCIATION	0	9311995
Smad4 (Co-Smad)#pro ⇨ Smad2/3 (R-Smads)\|_pho+Smad4 (Co-Smad)#com	HETERODIMER_ASSOCIATION	0	9311995
Smad6/7 (I-Smads)#pro ⇨ Smad2/3 (R-Smads)\|_pho+Smad4 (Co-Smad)#com	INHIBITION	-1	9311995
Smurf2#pro ⇨ Smad2/3 (R-Smads)\|_ubi+Smurf2#com	HETERODIMER_ASSOCIATION	0	11016919
Sp1#pro ⇨ MIF#pro	BRIDGED:CATALYSIS+TRANSLATION	1	18034423
Syk#pro ⇨ Syk\|Tyr519_pho\|Tyr518_pho\|active#pro	STATE_TRANSITION	0	21677049,23523010,16862125
Syk\|Tyr519_pho\|Tyr518_pho\|active#pro ⇨ Btk\|active#pro	CATALYSIS	1	22101734
Syk\|Tyr519_pho\|Tyr518_pho\|active#pro ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,7508932,7513165,22685316
Syk\|Tyr519_pho\|Tyr518_pho\|active#pro ⇨ PI3K\|active#pro	CATALYSIS	1	10805725,10473597,15646653
Syk\|Tyr519_pho\|Tyr518_pho\|active#pro ⇨ PKC_delta_\|active#pro	CATALYSIS	1	23523010
TAB1+TAB2\|_pho+TAK1\|_pho\|active#com ⇨ ECSIT+MEKK1\|active+TAB1+TAB2\|_pho+TAK1\|_pho\|active+TRAF6\|K63_ubi\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	12242293,10465784
TAB2#pro ⇨ TAB2\|_pho#pro	STATE_TRANSITION	0	11518704
TAK1#pro ⇨ TAK1\|_pho\|active#pro	STATE_TRANSITION	0	23523010
TAK1\|_pho\|active#pro ⇨ IKK _alpha_\|_pho\|active#pro	CATALYSIS	1	11460167
TAK1\|_pho\|active#pro ⇨ IKK _beta_\|_pho\|active#pro	CATALYSIS	1	11460167,16125763
TAK1\|_pho\|active#pro ⇨ MKK3\|_pho\|active#pro	CATALYSIS	1	11460167
TAK1\|_pho\|active#pro ⇨ MKK6\|_pho\|active#pro	CATALYSIS	1	11460167
TANK#pro ⇨ IKK_epsilon_\|active+TANK+TBK1#com	HETERODIMER_ASSOCIATION	0	16125763
TANK#pro ⇨ TANK\|active#pro	STATE_TRANSITION	0	16712718
TANK+TBK1+TRAF2\|Thr117_pho#com ⇨ I_kappa_B\|Ser_pho#pro	CATALYSIS	1	12133833,10581243,19666608
TANK+TBK1+TRAF2\|Thr117_pho#com ⇨ NF-_kappa_B\|active#pro	CATALYSIS	1	12133833,10581243,19666608
TBK1#pro ⇨ IKK_epsilon_\|active+TANK+TBK1#com	HETERODIMER_ASSOCIATION	0	16125763
TGF_beta+TGF_beta_ RI+TGF_beta_ RII#com ⇨ Smad2/3 (R-Smads)\|_pho\|active#pro	CATALYSIS	1	9311995,9346966,9346908
TGF_beta+TGF_beta_ RI+TGF_beta_ RII#com ⇨ TAK1\|_pho\|active#pro	CATALYSIS	1	11518704,8638164
TGF_beta+TGF_beta_ RI+TGF_beta_ RII#com ⇨ p21Ras\|active#pro	CATALYSIS	1	7786285,8607978,8479530,8599089
TIRAP#pro ⇨ MyD88\|hm2+TIRAP#com	HETERODIMER_ASSOCIATION	0	15229469
TLR1/2+triacylated lipopeptide#com ⇨ MyD88\|hm2+TIRAP#com	CATALYSIS	1	15229469
TLR2/6+diacylated lipopeptide#com ⇨ MyD88\|hm2+TIRAP#com	CATALYSIS	1	15229469
TLR3+dsRNA#com ⇨ TRIF\|hm2\|active#pro	CATALYSIS	1	15229469,12855817
TLR4#pro ⇨ CD14+LPS+MD-2+TLR4#com	HETERODIMER_ASSOCIATION	0	10196138
TLR7/8+ssRNA#com ⇨ MyD88\|hm2\|active#pro	CATALYSIS	1	15229469
TNF+TNFR+TRADD#com ⇨ RIP+TRADD+TRAF2#com	KNOWN_TRANSITION_OMITTED	0	8552378
TPL2\|_pho\|active#pro ⇨ MEK\|_pho\|active#pro	CATALYSIS	1	1322500
TPL2\|_pho\|active#pro ⇨ TNF#pro	BRIDGED:CATALYSIS+TRANSLATION	1	11163183,18515182,18291670
TRAF6#pro ⇨ TRAF6\|_pho#pro	STATE_TRANSITION	0	8837778,11518704
TRAF6\|K63_ubi\|_pho\|active#pro ⇨ ECSIT+MEKK1\|active+TAB1+TAB2\|_pho+TAK1\|_pho\|active+TRAF6\|K63_ubi\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	12242293,10465784
TRAF6\|K63_ubi\|_pho\|active#pro ⇨ IKK _gamma_\|_ubi\|active#pro	CATALYSIS	1	11057907,17562858
TRAF6\|K63_ubi\|_pho\|active#pro ⇨ IRF-5\|K63_ubi\|active#pro	CATALYSIS	1	18824541,19786094,15665823
TRAF6\|_pho#pro ⇨ TRAF6\|K63_ubi\|_pho\|active#pro	STATE_TRANSITION	0	11057907,18634786
TRIF#pro ⇨ TRIF\|hm2\|active#pro	STATE_TRANSITION	0	15229469,12855817
TSC1/2\|active#pro ⇨ 4EBP1\|active#pro	CATALYSIS	1	12172553
TSC1/2\|active#pro ⇨ Rheb\|active#pro	INHIBITION	-1	15094766
TSC1/2\|active#pro ⇨ TSC1/2\|_pho#pro	STATE_TRANSITION	0	15094766,12172553,15851026
TSC1/2\|active#pro ⇨ TSC1/2\|_pho\|active#pro	STATE_TRANSITION	0	14651849
TSC1/2\|active#pro ⇨ p70 S6K\|_pho\|active#pro	INHIBITION	-1	10567225,15094766,12172553
TTP#pro ⇨ CXCL1#pro	CATALYSIS	1	18250465
TXA_2#sim ⇨ TXB_2#sim	STATE_TRANSITION	0	6794395,6803534,6091982,3144211
Tollip#pro ⇨ Tollip\|_pho#pro	STATE_TRANSITION	0	10854325
TxS#pro ⇨ TXA_2#sim	CATALYSIS	1	6803534,1691652,21865441
Tyk2#pro ⇨ Jak1\|_pho\|active#pro	CATALYSIS	1	7504784,7504785,23219158
Tyk2#pro ⇨ Tyk2\|_pho\|active#pro	STATE_TRANSITION	0	8055912,23219158
Tyk2\|_pho\|active#pro ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+STAT1\|hm2\|Y701_pho\|active+STAT2\|Y689_pho\|active+Tyk2\|_pho\|active#com_1	CATALYSIS	1	7504785,7579387
Tyk2\|_pho\|active#pro ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+Tyk2\|_pho\|active#com	HETERODIMER_ASSOCIATION	0	11070173
Tyk2\|_pho\|active#pro ⇨ IFN-_alpha_+IFN-_beta_+IFNAR1\|_pho+IFNAR2\|_pho+Jak1\|_pho\|active+Tyk2\|_pho\|active#com_1	CATALYSIS	1	11070173
Tyk2\|_pho\|active#pro ⇨ IRS1\|_pho\|active#pro	CATALYSIS	1	8550573
Tyk2\|_pho\|active#pro ⇨ IRS2\|_pho\|active#pro	CATALYSIS	1	8550573
Tyk2\|_pho\|active#pro ⇨ Tyk2#pro	STATE_TRANSITION	0	7629131
Ubc13+Uev1A#com ⇨ TRAF6\|K63_ubi\|_pho\|active#pro	CATALYSIS	1	11057907,18634786
Ubiquitin#sim ⇨ IRF-5\|K63_ubi\|active#pro	STATE_TRANSITION	0	18824541,19786094,15665823
Ubiquitin#sim ⇨ Mdm2+p53\|_ubi#com	STATE_TRANSITION	0	8653711
Ubiquitin#sim ⇨ Smad2/3 (R-Smads)\|_ubi+Smurf2#com	HETERODIMER_ASSOCIATION	0	11016919
Ubiquitin#sim ⇨ TRAF6\|K63_ubi\|_pho\|active#pro	STATE_TRANSITION	0	11057907,18634786
VHL#pro ⇨ HIF-1_alpha_\|Pro_hyd+VHL#com	HETERODIMER_ASSOCIATION	0	10878807,11504942
_alpha_4+_beta_1#com ⇨ ERK\|_pho\|active#pro	CATALYSIS	1	10530871
adenylate cyclase#pro ⇨ adenylate cyclase\|active#pro	STATE_TRANSITION	0	12958648,23994549
arachidonic acid#sim ⇨ LTA_4#sim	STATE_TRANSITION	0	6311078
c-Kit1#pro ⇨ PI3K\|active#pro	CATALYSIS	1	1380456,10805725,23219158,22544939,15292195,11289110,11585703,1370584
c-Kit1#pro ⇨ Raf\|active#pro	CATALYSIS	1	8196769,1370584
c-Myc#pro ⇨ c-Myc\|_pho\|active#pro	STATE_TRANSITION	0	11018017
c-Myc\|_pho\|active#pro ⇨ FasL CD178#pro	BRIDGED:CATALYSIS+TRANSLATION	1	12655294
c-Src#pro ⇨ c-Src\|_pho\|active#pro	CATALYSIS	1	6283105
c-Src#pro ⇨ c-Src\|_pho\|active#pro_1	STATE_TRANSITION	0	23994549,6283105
c-Src\|_pho\|active#pro ⇨ Grb2\|active+SOS\|active+Shc\|active#com	CATALYSIS	1	8479536,9096689,2198577,6610834,7534287
c-Src\|_pho\|active#pro ⇨ PI3K\|active#pro	CATALYSIS	1	12958648,2399454,7713890,17016431,15313431,18411281,22101734
c-Src\|_pho\|active#pro ⇨ c-Src\|_pho\|active#pro	CATALYSIS	1	23994549,6283105
c-fos#pro ⇨ c-fos\|_pho\|active#pro	STATE_TRANSITION	0	8248197
c-fos\|_pho\|active#pro ⇨ c-fos\|_pho+c-jun\|_pho#com	HETERODIMER_ASSOCIATION	0	8170999,8912180
c-jun#pro ⇨ c-jun\|_pho\|active#pro	STATE_TRANSITION	0	8224842
c-jun\|_pho\|active#pro ⇨ c-fos\|_pho+c-jun\|_pho#com	HETERODIMER_ASSOCIATION	0	8170999,8912180
c-jun\|_pho\|active#pro ⇨ c-jun#pro	BRIDGED:CATALYSIS+TRANSLATION	1	7709430,8912180
cAMP#sim ⇨ PKA\|active#pro	CATALYSIS	1	4372627,9242925
cFLIP_L#pro ⇨ Caspase-8\|hm2\|active#pro	INHIBITION	-1	15491504,9880531,15317488
cFLIP_L#pro ⇨ RIP+Raf+TRAF1+TRAF2+cFLIP_L#com	KNOWN_TRANSITION_OMITTED	0	15491504
cFLIP_S#pro ⇨ Caspase-8\|hm2\|active#pro	INHIBITION	-1	15491504,9880531,15317488
eIF4E#pro ⇨ eIF4E\|_pho\|active#pro	STATE_TRANSITION	0	15254222
eNOS#pro ⇨ eNOS\|_pho\|active#pro	STATE_TRANSITION	0	10376602,10376603
histone H3#pro ⇨ histone H3\|Ser10_pho#pro	STATE_TRANSITION	0	10469656
mTOR#pro ⇨ mTOR\|_pho\|active#pro	STATE_TRANSITION	0	10910062,24121838,15094766
mTOR\|_pho\|active#pro ⇨ 4EBP1\|_pho#pro	CATALYSIS	1	24240150,10567225,15094766
mTOR\|_pho\|active#pro ⇨ p70 S6K\|_pho\|active#pro	CATALYSIS	1	10567225,15094766,12172553
miR-125b#ant ⇨ STAT3#pro	INHIBITION	-1	21368288,19559694
miR-125b#ant ⇨ TNF#pro	INHIBITION	-1	18515182,18291670
miR-127#ant ⇨ F_c_gamma_RI (CD64)#pro	INHIBITION	-1	22287715
miR-146a#ant ⇨ CCL5#pro	INHIBITION	-1	18515182
miR-146a#ant ⇨ CXCL8#pro	INHIBITION	-1	18515182
miR-146a#ant ⇨ IRAK1#pro	INHIBITION	-1	18515182,19596990
miR-146a#ant ⇨ IRAK2#pro	INHIBITION	-1	19596990
miR-146a#ant ⇨ STAT1#pro	INHIBITION	-1	20850013
miR-146a#ant ⇨ TNF#pro	INHIBITION	-1	18515182,18291670
miR-146a#ant ⇨ TRAF6#pro	INHIBITION	-1	18515182,18291670,23848342,19596990
miR-155#ant ⇨ CCL5#pro	INHIBITION	-1	18515182
miR-155#ant ⇨ CXCL8#pro	INHIBITION	-1	18515182
miR-155#ant ⇨ FADD#pro	INHIBITION	-1	18291670,18515182
miR-155#ant ⇨ IKK_epsilon_#pro	INHIBITION	-1	18291670,18515182
miR-155#ant ⇨ RIP#pro	INHIBITION	-1	18291670,18515182
miR-155#ant ⇨ SHIP-1#pro	INHIBITION	-1	19359473
miR-155#ant ⇨ SOCS1#pro	INHIBITION	-1	19144316,19699171
miR-155#ant ⇨ TAB2#pro	INHIBITION	-1	19193853
miR-155#ant ⇨ TNF#pro	INHIBITION	-1	18515182,18291670
miR-155#ant ⇨ c-fos#pro	INHIBITION	-1	21385848
miR-16#ant ⇨ Bcl2#pro	INHIBITION	-1	18931683
miR-16#ant ⇨ CXCL8#pro	INHIBITION	-1	18515182
miR-16#ant ⇨ IL-6#pro	INHIBITION	-1	18515182
miR-16#ant ⇨ TNF#pro	INHIBITION	-1	18515182,18291670
miR-17-5p#ant ⇨ CREB#pro	INHIBITION	-1	21972292
miR-17-5p#ant ⇨ STAT3#pro	INHIBITION	-1	21368288,19559694
miR-17-5p#ant ⇨ TGF_beta_ RII#pro	INHIBITION	-1	21972292
miR-17-5p#ant ⇨ p38#pro	INHIBITION	-1	19559694
miR-203#ant ⇨ SOCS3#pro	INHIBITION	-1	18291670,24607843
miR-221#ant ⇨ IRF-2#pro	INHIBITION	-1	24607843
miR-221#ant ⇨ SOCS3#pro	INHIBITION	-1	18291670,24607843
miR-221#ant ⇨ c-Kit1#pro	INHIBITION	-1	16330772
miR-27a#ant ⇨ IL-10#pro	INHIBITION	-1	24835395
miR-302d#ant ⇨ p21 CIP1#pro	INHIBITION	-1	18978791
p21Ras#pro ⇨ p21Ras\|active#pro	STATE_TRANSITION	0	7786285,8607978,8479530,8599089
p21Ras\|active#pro ⇨ PKC_zeta_\|active#pro	CATALYSIS	1	10224130
p21Ras\|active#pro ⇨ Raf\|active#pro	CATALYSIS	1	8196769,1370584
p21Ras\|active#pro ⇨ p21Ras#pro	STATE_TRANSITION	0	2833817
p27 KIP1\|active#pro ⇨ p27 KIP1\|_pho#pro	STATE_TRANSITION	0	12146978
p300 HAT#com ⇨ iNOS#pro	BRIDGED:INHIBITION+TRANSLATION	-1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
p300 HAT#pro ⇨ p300 HAT#com	HETERODIMER_ASSOCIATION	0	10075656
p38#pro ⇨ p38\|_pho\|active#pro	STATE_TRANSITION	0	15313431
p38\|_pho\|active#pro ⇨ AP1\|_pho\|active#pro	CATALYSIS	1	8137421,8912180
p38\|_pho\|active#pro ⇨ ATF-2\|_pho\|active#pro	CATALYSIS	1	7824938,7535770,7824938
p38\|_pho\|active#pro ⇨ ELK\|_pho\|active#pro	CATALYSIS	1	8846788,8978682
p38\|_pho\|active#pro ⇨ HIF-1_alpha_\|_pho+HIF-1_beta_#com	CATALYSIS	1	10551817,11585703,12213597
p38\|_pho\|active#pro ⇨ MAPKAPK2\|_pho\|active#pro	CATALYSIS	1	8666821
p38\|_pho\|active#pro ⇨ MNK 1/2\|_pho\|active#pro	CATALYSIS	1	9155017
p38\|_pho\|active#pro ⇨ MSK 1/2\|_pho\|active#pro	CATALYSIS	1	9687510
p38\|_pho\|active#pro ⇨ Mdm2+p53\|_pho#com	CATALYSIS	1	7890669,7510706,9607138
p38\|_pho\|active#pro ⇨ SOCS3#pro	BRIDGED:CATALYSIS+TRANSLATION	1	22973511,23219158,15032587,10433356,19422799,18291670,24607843
p38\|_pho\|active#pro ⇨ STAT1_alpha_\|hm2\|Y701_pho\|S727_pho\|active#pro	CATALYSIS	1	8557638,15266021,7543024
p38\|_pho\|active#pro ⇨ Smad6/7 (I-Smads)#pro	BRIDGED:CATALYSIS+TRANSLATION	1	9759503,10652273,9335507
p38\|_pho\|active#pro ⇨ c-fos\|_pho+c-jun\|_pho#com	CATALYSIS	1	8170999,8912180
p38\|_pho\|active#pro ⇨ p38#pro	STATE_TRANSITION	0	16380512
p40_phox+p47_phox+p67_phox#com ⇨ Rac+Rap1a+gp91_phox+p22_phox+p40_phox+p47_phox+p67_phox#com	HETERODIMER_ASSOCIATION	0	22544939,18094534,17277894
p53#pro ⇨ Mdm2+p53#com	HETERODIMER_ASSOCIATION	0	1535557
p53\|_pho\|active#pro ⇨ IFN-_gamma_#pro	BRIDGED:INHIBITION+TRANSLATION	-1	8700208,9834094,1602132,23630228
p53\|_pho\|active#pro ⇨ IL-12 p35#pro	BRIDGED:INHIBITION+TRANSLATION	-1	14568984,17924060,15811878,23630228
p53\|_pho\|active#pro ⇨ IL-6#pro	BRIDGED:INHIBITION+TRANSLATION	-1	22312110,2405250,2786029,15811878,23177475,18515182
p53\|_pho\|active#pro ⇨ Mdm2#pro	BRIDGED:CATALYSIS+TRANSLATION	1	8440237
p53\|_pho\|active#pro ⇨ TNF#pro	BRIDGED:INHIBITION+TRANSLATION	-1	22312110,2181276,22147692,23177475,15811878,23630228,18515182,18291670
p53\|_pho\|active#pro ⇨ iNOS#pro	BRIDGED:INHIBITION+TRANSLATION	-1	7508926,7510419,22312110,9671763,9065784,12057007,10075021,12213597,10848596
p53\|_pho\|active#pro ⇨ p21 CIP1#pro	BRIDGED:CATALYSIS+TRANSLATION	1	9694869,8242752,18978791
p53\|_pho\|active#pro ⇨ pro-IL-1_beta_#pro	BRIDGED:INHIBITION+TRANSLATION	-1	8413223,23630228,8943727
p70 S6K#pro ⇨ p70 S6K\|_pho\|active#pro	STATE_TRANSITION	0	10567225,15094766,12172553
p90RSK#pro ⇨ p90RSK\|_pho\|active#pro	STATE_TRANSITION	0	2842685
p90RSK\|_pho\|active#pro ⇨ BAD\|_pho#pro	CATALYSIS	1	9381178,9346240,14678993
p90RSK\|_pho\|active#pro ⇨ CREB\|_pho\|active#pro	CATALYSIS	1	9687510
p90RSK\|_pho\|active#pro ⇨ GSK3\|Ser_pho#pro	CATALYSIS	1	8307153
p90RSK\|_pho\|active#pro ⇨ c-fos\|_pho\|active#pro	CATALYSIS	1	8248197
p90RSK\|_pho\|active#pro ⇨ c-jun\|_pho\|active#pro	CATALYSIS	1	8224842
p90RSK\|_pho\|active#pro ⇨ p27 KIP1\|active#pro	BRIDGED:INHIBITION+TRANSLATION	-1	10827191,11094066
pro-IL-18#pro ⇨ IL-18#pro	STATE_TRANSITION	0	24115947
pro-IL-1_beta_#pro ⇨ IL-1_beta_#pro	STATE_TRANSITION	0	1574116
procaspase-1#pro ⇨ Caspase-1\|active#pro	STATE_TRANSITION	0	11390368,19915568,23307811,22753929
procaspase-7#pro ⇨ Caspase-7#pro	STATE_TRANSITION	0	19343209
procaspase-8#pro ⇨ Caspase-8\|hm2\|active#pro	STATE_TRANSITION	0	15491504,9880531,15317488
v-ATPase#pro ⇨ v-ATPase\|active#pro	STATE_TRANSITION	0	23159466